31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[0512] Benzyl piperazine-1-carboxylate 23 (27 .3 mL,142.2 mmol) was dissolved in dry THF (313.1 mL) andoxetan-3-one (12.29 g, 10.93 mL, 170.6 mmol) was added.The resulting solution was cooled in an ice-bath. NaBH(Oac )3 (59.99 g, 284.4 mmol) was added portionwise over 30mins, about a quarter was added. Mixture removed from icebath, allowed to warm to room temperature then continuedadding the NaBH(Oac )3 portionwise over 30 mins. On completeaddition, an exotherm from 22¡ã C. slowly to 32¡ã C. wasobserved, whereby the mixture was subsequently cooled onan ice bath until an internal of 22¡ã C. was reached. The icebath was removed and the reaction mixture’s internal tempwas steady at 22¡ã C. The mixture was stirred at room temperatureovernight. [0513] The resulting white suspension was quenched byaddition of 2M sodium carbonate solution (approx 150 mL)(pH=8) and concentrated under reduced pressure to removeTHF. Product was then extracted with EtOAc (3×250 mL).Organics were combined, dried over MgS04 , filtered andconcentrated under reduced pressure to leave product 24 as awhite solid (32.7 g 83percent yield). 1H NMR (500 MHz, DMSOd6)o 7.39-7.30 (m, 5H), 5.07 (s, 2H), 4.52 (t, 2H), 4.42 (t,2H), 3.43-3.39 (m, 5H) and 2.22 (t, 4H). MS (ES+) 276.8., 31166-44-6
As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference£º
Patent; Charrier, Jean-Damien; Davis, Christopher John; Fraysse, Damien; Etxebarria I Jardi, Gorka; Pegg, Simon; Pierard, Francoise; Pinder, Joanne; Studley, John; Zwicker, Carl; Sanghvi, Tapan; Waldo, Michael; Medek, Ales; Shaw, David Matthew; Panesar, Maninder; Zhang, Yuegang; Alem, Naziha; US2015/158872; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics