67455-41-8, 4-(Piperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67455-41-8
Add 2-chloro-4-(cyclopentylamino) pyrimidine-5-carboxylic acid ethyl ester (1.3 g, 4.82 mmol) to an eggplant-shaped bottle containing 20 mL of isopropanol, and add Et3N (0.49 g, 4.82 mmol), 4-Piperazinyl aniline (1.11 g, 6.27 mmol), refluxed after the addition, after 6.0 hours TLC showed that the reaction was complete, and concentrated under reduced pressure to give the target crude product (1.31 g), CH2Cl2: MeOH = 20:1 to obtain pure product (1.06 g, 51.7%).
As the paragraph descriping shows that 67455-41-8 is playing an increasingly important role.
Reference£º
Patent; FIRST AFFILIATED HOSPITAL ZHENGZHOU UNIV; Zhengzhou University The First Affiliated Hospital; KAN QUANCHENG; Kan Quancheng; TIAN XIN; Tian Xin; ZHANG XIAOJIAN; Zhang Xiaojian; YANG ZHIHENG; Yang Zhiheng; DU YUE; Du Yue; CHENG WEIYAN; Cheng Weiyan; YUAN YONGLIANG; Yuan Yongliang; WANG SUHUA; Wang Suhua; (29 pag.)CN108299312; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics