With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 4; (8aS)-N-q,3-Dichlorophenyl)-l,3-dioxo-2-ralphaS,2R)-2- phenylcyclopropyllhexahydroimidazorLS-alpyrazine-TflHVcarboxamide (D3); Step 1 : 1-tert-Butyl 3-methyl (3S)-4-((r(lS.2R)-2-phenylcvclopropyllaminolcarbonvn-1.3- piperazinedicarboxylate (Dl); A solution of l-tert-buty 3-methyl (35)-l,3-piperazinedicarboxylate (AA3) in DCM (0.17 M) was added to a stirred solution of [(li?,25)-2-isocyanatocyclopropyl]benzene (1.0 eq.) in DCM (0.17 M) and the mixture was stirred at RT for 1 h. Solvents were evaporated under reduced pressure to give the title compound that was used as such in next step. MS (ES+) C2iH2gN3theta5 requires 403, found: 404 (M+H)+., 314741-39-4
314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita; WO2010/23480; (2010); A1;,
Piperazine – Wikipedia
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