120737-78-2, tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2-(5-chloro-2,4-dimethoxyphenyl)-7-(4-(2-chloropyrimidin-4- yl)piperazin-l-yl)imidazo[ l,2-a|pyridine 311 (200 mg, 0.41 mmol) and tert-butyl 2- methylpiperazine-1-carboxylate (164 mg, 0.824 mmol) was heated at 125 C in a microwave reactor for 3 h. The reaction mixture was diluted with water; the precipitate was collected by filtration, washed with water and dried. The crude compound was purified by combi-flash companion (silica gel, NH4OH/CH3OH CH2CI2) to provide tert-butyl 4-(4-{4-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl}pyrimidin-2-yl)-2-methylpiperazine-1-carboxylate 312j (125 mg, 47%) as an off-white solid. lH NMR (300 MHz, DMSO-d6): delta 8.36 (d, ./ = 7.5 Hz, i l l). 8.17 (s, 1H), 8.03 (s, 1H), 7.92 (d, J = 6 Hz, I H), 6.87-6.84 (m, 2H), 6.71 (s, 1H), 6.18 (d, J = 6 Hz, IH), 4,51 (dd, J = 13.2, 20.7 Hz, 2H), 4.18 (bs, IH), 4.01 (s, 3H), 3.93 (s, 3H), 3 ,78-3.68 (m, 4H), 3.33-3.12 (m, 4H), 3.07-2.99 (m, 2H), 2.90-2.81 (m, IH), 1.42 (s, 9H), 1.05 (d, ./ 6.6 I zeta. 3H); HPLC (Method 1) 96.1% (AUC), fR – 13.0 min.; ESI+APCI MS rn/z 649 M + l |, 120737-78-2
120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics