With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
EXAMPLE 7 9-{4-[4-(4-Trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide Prepared analogously to Example 2 b from 1-(4-trifluoromethyl-phenyl)-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide. Yield: 0.23 g (48.7% of theoretical). Melting point: 176 C., 30459-17-7
As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.
Reference£º
Patent; Boehringer Ingelheim Pharm GmbH & Co, KG; US6818644; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics