59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
59878-57-8, To a round bottom flask containing 2-(4,4,5,5-Tetramethyl-l,3,2-dioxaborolan-2-yl)benzoic acid (1.00 g, 4.03 mmol) was added DCM (40 mL), diisopropylethylamine (1.05 mL, 6.04 mmol) and HBTU (2.29 g, 6.04 mmol). The reaction mixture was stirred for 30 min before adding cyclopropylpiperazine-l-ylmethanone (0.86 mL, 6.04 mmol). The reaction was stirred overnight before the excess solvent with removed in vacuo and the crude material purified via flash column chromatography (EtOAc:MeOH 10:1) affording (4- (Cyclopropanecarbonyl)piperazin-l-yl)(2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl)methanone as a white solid (1.08 g, 2.82 mmol, 70%) in a mixture of rotamers (2:1). The shifts relating to the minor rotamer has been donated with an asterisk.* *H NMR (400 MHz, CDCh) d = 7.81 (d, J = 7.4 Hz, 1H + 1H*), 7.45 (td, J = 7.6, 1.5 Hz, 1H + 1H*), 7.35 (td, / = 7.5, 1.3 Hz, 1H + 1H*), 7.22 (d, J = 7.5 Hz, 1H + 1H*), 3.86 – 3.69 (m, 4H, 4H*), 3.67 – 3.50 (m, 2H, 2H*), 3.34 – 3.07 (m, 2H, 2H*), 1.81 – 1.52 (m, 1H + 1H*), 1.29 (s, 12H + 12H*), 1.04 – 0.95 (m, 2H + 2H*), 0.67 – 0.87 (m, 2H + 2H*); 13C NMR (100 MHz, CDCh) d = 172.3 (1C + 1C*), 171.3 (1C + 1C*), 142.3 (1C + 1C*), 135.7 (1C + 1C*), 131.2 (1C + 1C*), 128.2 (1C + 1C*), 125.4 (1C + 1C*), 84.1 (2C + 2C*), 47.3 (1C*), 47.0, 45.2 (1C*), 44.9, 41.9 (2C), 41.6 (2C*) 24.9 (4C + 4C*), 11.0 (1C + 1C*), 7.65 (2C + 2C*) (the carbon bearing the boron substituent is not observed); IR (v, cm 1): 2970, 1634, 1467, 1213, 1014, 741; HRMS (ESI) for C2iH3o10BN204 [M+H]+ requires 384.2220 found 384.2218; Mp: 85 – 87C.
As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.
Reference£º
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; GOUVERNEUR, Veronique; CORNELISSEN, Bart; WILSON, Thomas Charles; (152 pag.)WO2019/186135; (2019); A1;,
Piperazine – Wikipedia
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