With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122833-04-9,2-Methoxy-4-(4-methylpiperazin-1-yl)aniline,as a common compound, the synthetic route is as follows.
General procedure: To the solution of 7 (0.54 g, 1.5 mmol) in isopropanol (8 mL) wasadded 10a-d (0.31 g, 1.5 mmol) and p-Toluenesulfonic acid (0.26 g,1.5 mmol). The resulting solution was stirred at 95 C for 6 h. When thecompletion of the reaction, the reaction mixture was quenched withwater (8 mL) and adjusted pH to 8 with sodium bicarbonate. Then themixture was extracted with ethyl acetate (8 mL) for 3 times and thecombined organic layers were washed with water, brine, dried overNa2SO4 and the solvent was evaporated under reduced pressure. Afterpurifying through column chromatography using dichloromethane/methanol as an eluent, the target products 11a-d were obtained in satisfactoryyields.
122833-04-9, 122833-04-9 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline 20136253, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Gong, Ping; Guo, Ming; Liu, Sicong; Miao, Xiuqi; Xing, Lingyun; Yin, Shiliang; Zhai, Xin; Zhang, Dajun; Zhang, Hong; Bioorganic Chemistry; vol. 94; (2020);,
Piperazine – Wikipedia
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