With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140447-78-5,1-(2-N-Boc-Aminoethyl)piperazine,as a common compound, the synthetic route is as follows.
Compound 10 10- { 3 -[4-(N-Boc-2 -amino)ethylpiperazinyl] propyl } -2- dimethylsulfamidolphenothiazineTo a stirred solution of the phenothiazine chloro derivative 9 (382 mg, 1.0 mmol), potassium carbonate (500 mg,3.62 mmol), and l-(2-N-Boc- aminoethyl)piperazine (229 mg, 1.0 mmol) in methyl ethyl ketone (20 mL) was added sodium iodide (150 mg, 1 mmol). The reaction mixture was stirred for 24 h at reflux under an atmosphere of argon. The reaction mixture was filtered, and the filtrate was concentrated under vacuum. The residue was partitioned between ethyl acetate (20 mL) and brine (10 mL). The organic layer was dried over anhydrous sodium sulphate, filtered, and evaporated. The resulting residue was purified by silica gel chromatography (9:1 CH2Cl2:MeOH) to give 10 (410 mg, 71%) as a foam. MS(ESI): m/z 576 (M+H)., 140447-78-5
140447-78-5 1-(2-N-Boc-Aminoethyl)piperazine 1514401, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; IMMUNE CONTROL, INC.; WO2008/27521; (2008); A1;,
Piperazine – Wikipedia
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