With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.
601 2-(4-(4-nitrophenyl)piperazin-1-yl)ethan-1-ol (0.9 g, 3.58 mmol) was dissolved in 10 mL 6 EtOH, further 10 mL 7 water was added under stirring. 203 Iron powder (0.6 g, 10.75 mmol) and 67 NH4Cl (0.383 g, 7.16 mmol) were then added. The resulting mixture was heated at 90 C. for 1-2 h. The reaction was monitored by LCMS. After completion of reaction, mixture was filtered through celite bed, solvent form the filtrate was removed under reduced pressure. Water was added to the residue and extracted using 30 MeOH: 82 CH2Cl2 (10%), dried over Na2SO4. The solvent was removed under reduced pressure to afford 604 2-(4-(4-aminophenyl) piperazin-1-yl) ethan-1-ol (0.550 g, 70%) as a brown solid. (0626) LCMS: 221 [M+1]+
5521-38-0, 5521-38-0 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 2763936, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Piperazine – Wikipedia
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