1403898-64-5, (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine- 1-carboxylate (100 mg, 0.43 mmol) in acetonitrile (5 mL), were added DIPEA (0.8 mL, 4.34 mmol) and 6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl (2927) trifluoromethanesulfonate (145 mg, 0.43 mmol) at room temperature. The reaction mixture was heated at 80 C for 3 h. The reaction mixture was cooled to room temperature and solvent was removed under reduced pressure to obtain the crude product, which was purified by flash column chromatography (Column: 12 g silica; Solvent run: 2-3% MeOH (10% NH4OH in chloroform) to obtain a tert-butyl (2R,5R)-4-(6-cyano-1- methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-5-(hydroxymethyl)-2- methylpiperazine-1-carboxylate (120 mg, 67% yield). LCMS: m/z, 414.2 (M+H); (2928) retention time 1.36 min. [LCMS Method: Column: Waters Acquity UPLC BEH C18 (2.1 x 50 mm) 1.7 mm, Mobile phase A: 10 mM NH4OAc:acetonitrile (95:5); Mobile phase B: 10 mM NH4OAc:acetonitrile (5:95), Gradient = 20-100 % B over 2 minute, then a 0.3 minute hold at 100 % B; Temperature: 50 C; Flow rate: 0.7 mL/min; Detection: UV at 220 nm]., 1403898-64-5
1403898-64-5 (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate 71003242, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; CHUPAK, Louis S.; DARNE, Chetan Padmakar; DING, Min; GENTLES, Robert G.; HUANG, Yazhong; KAMBLE, Manjunatha Narayana Rao; MARTIN, Scott W.; MANNOORI, Raju; MCDONALD, Ivar M.; OLSON, Richard E.; RAHAMAN, Hasibur; JALAGAM, Prasada Rao; ROY, Saumya; TONUKUNURU, Gopikishan; VELAIAH, Sivasudar; WARRIER, Jayakumar Sankara; ZHENG, Xiaofan; TOKARSKI, John S.; DASGUPTA, Bireshwar; REDDY, Kotha Rathnakar; RAJA, Thiruvenkadam; (0 pag.)WO2020/6018; (2020); A1;,
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