13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
INTERMEDIATE 66(S)-tert-RvLty 1 – |”2-(4-acetylpiperazin- 1 -yl)-8-methylquinolin-3 -yl] ethylcarbatnateIntermediate 4 (150 mg, 0.47 mmol), 1-acetylpiperazine (300 nig, 2.34 mmol), DIPEA (0.42 niL, 2.34 mmol) and NMP (3 mL) were combined in a sealed tube and heated to 14O0C for 48 h. After cooling, the reaction mixture was dissolved in a 1 :1 mixture of EtOAc and Et2O (100 mL) and washed with saturated brine (3 x 25 mL). The organic layer was dried (MgSO4) and concentrated in vacuo. Purification by column chromatography on silica, eluting with 0-100% EtOAc in isohexane, afforded the title compound (151 mg, 78%) as a white solid. LCMS (ES+) 413 (M+H)+.
13889-98-0, 13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
Piperazine – Wikipedia
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