With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55276-43-2,1-Methanesulfonylpiperazine,as a common compound, the synthetic route is as follows.
Example 1; This Example illustrates the preparation of N- (3-phenyl-3- [4- METHANESULPHONYLPIPERAZIN-1-YL] PROPYL)-4- [2- (4-METHANESULPHONYLPHENYLSULPHONYL) ethyl] – piperidine (Compound No. 8, Table I). N- (3-Phenyl-3-chloropropyl)-4- [2- (4-methanesulphonylphenylsulphonyl) ethyl] – piperidine (prepared according to Method D; 180mg) was added to a solution of N- methanesulphonylpiperazine (61mg) and triethylamine (0. 102ML) in dichloromethane (10ML) and the mixture was allowed to stand at room temperature for 16 hours. The reaction mixture was poured onto a 20g silica Bond Elut eluted with a solvent gradient (ethyl acetate-25% methanol/ethyl acetate). The title compound was obtained, yield 67mg, MHF 612. NMR (CDC13) : 1.6-1. 8 (m, 7H), 2.2-2. 6 (m, 9H), 2.7 (m, 1H), 2.75 (s, 3H), 3.2 (m, 11H), 3.45 (m, 1H), 7.2 (d, 2H), 7.3 (m, 3H), 8.2 (m, 4H)., 55276-43-2
55276-43-2 1-Methanesulfonylpiperazine 709161, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; WO2004/56773; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics