109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1 – Methyl-piperazin-2-one hydrochloride (0.844 mmol, 127 mg) in dichloromethane was put on a column of Si-Carbonate (Silicycle, 1 g) and eluation with dichloromethane gave the free base 1 -methyl-piperazin-2- one. To this compound in 2-propanol (1 ml) were subsequently added 4-(1-bromo-8-methylimidazo[1 ,5- a]pyrazin-3-yl)cyclohexanone (0.649 mmol, 200 mg) and aluminium isopropoxide (1.469 mmol, 300 mg) and the mixture was stirred at 60 C for one hour. Sodium triacetoxyborohydride (1.298 mmol, 275 mg) was added and the mixture was stirred at 60 C overnight. Then the reaction mixture was diluted with dichloromethane and water, the dichloromethane layer isolated by a phase separation filter and concentrated in vacuo. The crude product was was purified by column chromatography (silica gel; gradient of dichloromethane to dichloromethane / methanol 92/8) to give 4-((trans)-4-(1-bromo-8-methylimidazo[1 ,5- a]pyrazin-3-yl)cyclohexyl)-1 -methylpiperazin-2-one (50 mg)., 109384-27-2
As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.
Reference£º
Patent; N.V. ORGANON; MAN de,, Adrianus Petrus Antonius; REWINKEL,, Johannes Bernardus Maria; JANS,, Christiaan Gerardus Johannes Maria; RAAIJMAKERS,, Hans Cornelis Andreas; WIJKMANS,, Jacobus Cornelis Henricus Maria; WO2011/95556; (2011); A1;,
Piperazine – Wikipedia
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