With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step 1 : tert-Butyl 4-benzylpiperazine-l-carboxylate (0754) [00268] To a solution of compound A3-1 (20.0 g, 107 mmol, 1.0 eq) and (0755) bromomethylbenzene (22.0 g, 129 mmol, 1.2 eq) in CH3CN (300 mL) was added K2CO3 (14.8 g, 107 mmol, 1.0 eq). The reaction mixture was stirred at 70 C for 16 hours. The reaction mixture was concentrated under reduced pressure. The mixture was diluted with water (50 mL) and the resultant mixture was extracted with EA (80 mL * 2). The combined organic layers were dried over NaiSO/t, filtered and concentrated to dryness under reduced pressure. The residue was purified by column chromatography over silica gel (petroleum ether: ethyl acetate = 1 :0 to 5: 1) to afford the title compound (16.8 g, 57% yield) as a white solid. ‘HNMR (400MHZ, CDCl3-i/) delta 7.34 – 7.23 (m, 5H), 3.50 (s, 2H), 3.46 – 3.38 (m, 4H), 2.43 – 2.33 (m, 4H), 1.45 (s, 9H), 57260-71-6
The synthetic route of 57260-71-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VIVACE THERAPEUTICS, INC.; LIN, Tracy Tzu-Ling Tang; KONRADI, Andrei W.; VACCA, Joseph; SHEN, Wang; COBURN, Craig; (231 pag.)WO2017/58716; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics