With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
Compound BB-17-1 (7.0g, 31.78mmol) was dissolved in dilute hydrochloric acid (6M, 150mL) with stirring until homogeneous under nitrogen protectionskid slowly dropwise a solution of sodium nitrite (4N, 30 mL), then stirred at room temperature about one hour, 100mL of water was added with ethylacetate and extracted (100mL ¡Á 3).The combined organic phases were washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, and under reduced pressure to removethe solvent, the resulting target compound BB-17-2 (7.5g, yield: 66%), was used directly in the next step without further purification.
31166-44-6, The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Changzhou Yin Sheng Pharmaceutical Co., Ltd.; Sichuan University; Zhang, Yang; Fu, Zhifei; Li, Jian; Chen, Shuhui; Wei, Yuquan; Tao, Xin; (65 pag.)CN105732602; (2016); A;,
Piperazine – Wikipedia
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