Month: April 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84477-85-0,Benzyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,84477-85-0

Step 2: K2CO3 (4 g, 0.029mol) was added into a solution of compound 219-2 (2.25 g, 14.5 mmol) and compound 219-3 (3.41 g, 14.5 mmol) in DMF (10 mL). The mixture was stirred at 160C for 4h, then poured into H2O. The mixture was extracted with EtOAc, dried over anhydrous sodium sulfate and concentrated, the crude product was purified by column chromatography to deliver compound 219-4 (2.8 g, yield 52%). MS ESI calcd for C20H23N3O4 [M+H]+ 370, found 370.

The synthetic route of 84477-85-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Hao; LIN, Jun; LI, Yunhui; WEI, Changqing; CHEN, Shuhui; LONG, Chaofeng; CHEN, Xiaoxin; LIU, Zhuowei; CHEN, Lijuan; (212 pag.)EP3124482; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 4-(4-nitrophenyl)piperazine- 1 -carboxylate (8.2 g, 26.68 mmol) inMeOH (100 mL) was purged using nitrogen and reduced pressure. Palladium on charcoal(10% wet) was added and the mixture was hydrogenated (50 psi) for 16 h. The reaction mixture was filtered through diatomaceous earth and concentrated under reduced pressure to give tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97%) as a dark blue oil used directly into the next step. C15H23N302 MS m/z 277.9 (M+H)., 182618-86-6

As the paragraph descriping shows that 182618-86-6 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BIGNAN, Gilles; CONNOLLY, Peter J.; HICKSON, Ian; MEERPOEL, Lieven; PANDE, Vineet; ZHANG, Zhuming; BRANCH, Jonathan; ROCABOY, Christian; TRABALON ESCOLAR, Luis B.; (521 pag.)WO2017/123542; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-methoxybenzeneacetic acid (5.0 g; 0.03009 mol) in CH2Cl2 (100 ml) was stirred at room temperature. 4-(4-Aminophenyl)-l-piperazinecarboxylic acid 1,1- dimethylethyl ester (8.35 g; 0.03009 mol) and Et3N (6.3 ml; 0.04514 mol) were added. Then, EDCI (5.77 g; 0.03009 mol) and HOBT (4.07 g; 0.03009 mol) were added to the mixture. The resultant reaction mixture was stirred overnight at room temperature. The solvent was evaporated in vacuo. The residue was washed with methanol, then dried. Yield: 11.9 g of intermediate 83 (93 %)., 170911-92-9

The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/148868; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of Palladium() acetate (6mg, 0.22mmol) 2-dicyclohexylphosphino-2?,6? -di-i-porpoxy-1,1?-biphenyl (22mg, 0.044mmol), and cesium carbonate (0.22g, 0.68mmol) were weighted out and the vial was purged with nitrogen, the bromo-contained intermediate 8d (0.44mmol) and a series of N-containing heterocyclic compounds (0.68mmol) solved in 1,4-dioxane (15mL) were added. The mixture was stirred at 100C for 16h. The reaction was filtered, concentrated and purified by silica gel column chromatography to give 18a-38a.

13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Article; Cao, Zhonglian; Fu, Wei; Ma, Xiaojun; Sun, Nannan; Wang, Yonghui; Xu, Jun; Zhou, Kaifeng; Zhu, Chen; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

889939-92-8, 2-(1-Methylpiperazin-2-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

889939-92-8, 974 mg of Nu,Nu-diisopropylethylamine and 724 mg of 2-(1 -methylpiperazin-2-yl)ethanol are added to a suspension of 1 g of 4-fluoro-1 -nitro-2-(propan-2-yloxy)benzene in 10 ml of acetonitrile. The reaction medium is microwave-heated at 1 10C for 6 hours and then concentrated to dryness under reduced pressure. Purification is carried out by flash chromatography on silica gel (40-63 microns), elution being carried out with a mixture of dichloromethane and methanol (100/0) to (90/10). 1 .15 g of 2-{1 -methyl-4-[4-nitro-3- (propan-2-yloxy)phenyl]piperazin-2-yl}ethanol are obtained in the form of a yellow oil.

The synthetic route of 889939-92-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stephanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice; WO2013/150036; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of II-B-3 from Step 2 in THF (2 mL), was added N-(alpha,alpha,alpha-trifluoro-p-tolyl)piperazine (187 mg, 0.81 mmol, 1.0 equiv.), followed by Et3N (1.61 mmol, 2.0 equiv.). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by chromatography. 1H NMR (400 MHz, CDCl3) delta ppm: 7.75 (m, 2H), 7.58 (m, 2H), 7.48 (d, 2H), 6.90(d, 2H), 3.76 (s, 3H), 3.74 (s, 2H), 3.65 (m, 4H), 3.22 (m, 4H)., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

438049-35-5, N-Boc-3-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3-1, Preparation of tert-butyl (3R)-3-ethyl-4-[3-fluoro-2-(methoxycarbonyl)-4-nitrophenyl]piperazine-1-carboxylate To a solution of tert-butyl-(3R)-3-ethylpiperazine-1-carboxylate (555 mg, 2.59 mmol) and methyl 2,6-difluoro-3-nitrobenzoate (843 mg, 3.89 mmol) in DMSO (2 mL) was added DIEA (0.90 mL, 5.2 mmol). The mixture was heated at 130 C. for 1 h. The mixture was purified by C18 reversed phase column chromatography to give the title compound (813 mg, 76% yield) as a brownish yellow gum. LCMS (M+H)+: 412.3., 438049-35-5

The synthetic route of 438049-35-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Crinetics Pharmaceuticals, Inc.; HAN, Sangdon; ZHU, Yunfei; KIM, Sun Hee; ZHAO, Jian; WANG, Shimiao; (146 pag.)US2019/367481; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 100-ml flask, 500 mg (2.68 mmol) of t-butyl piperazine-1-carboxylate was dissolved in 5 ml of water, followed by stirring. 1.6 ml of acetic acid and 1.09 g (13.4 mmol, 5.0 eq) of potassium cyanate dissolved in water were added, followed by stirring at room temperature for 4 hours. After completion of the reaction, a solid was obtained by filtration while washing with water. The solid thus obtained was dissolved in dichloromethane, and then washed with water. An organic layer was separated and washed with a NaCl aqueous solution, dehydrated and dried over MgSO4, and concentrated under reduced pressure to obtain 282 mg (46%) of a title compound., 57260-71-6

57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Dong-A ST Co., Ltd.; CHOI, Sung Pil; CHOI, Seul Min; SON, Byoung Hwa; KIM, Hyun Jung; KIM, Ju Mi; JANG, Byung Jun; SUNG, Ji Hyun; LEE, Ji Hye; KIM, Eunjin; KANG, Kyung Koo; KIM, Soon-Hoe; (142 pag.)EP3135669; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21091-98-5,(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone,as a common compound, the synthetic route is as follows.

Step: 3A-2Synthesis of (4- Amino-phenyl)-(4-methy 1-piperazin-l – l)-methanone.Procedure:Pd-C (150mg) was added to a solution of (4-Methyl-piperazin-l-yl)-(4-nitro-phenyl)- methanone (440mg, 1.7670mmol) in MeOH and stirred for 2hrs in a hydrogen atmosphere. The reaction was monitored by the TLC (10% MeOH: CHC13). The resultant was filtered through celite bed and concentrated to afford 380mg (98% yield) of (4-Amino-phenyl)-(4- methyl-piperazin- 1 -y l)-methanone., 21091-98-5

As the paragraph descriping shows that 21091-98-5 is playing an increasingly important role.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara; WO2012/59932; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

278788-66-2, (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of /ert-butyl (3f?)-3-(hydroxymethyl)piperazine-l -carboxylate (80.0 g, 370 mmol, 1.0 eq) in Ethyl acetate (1400 mL) was added NaHCOa (93.2 g, 1.1 1 mol, 43.2 niL, 3.0 eq), H20 (700 mL) and benzyl carbonochloridate (82.0 g, 481 mmol, 68.4 mL, 1.30 eq). The mixture was stirred at 25 C for 12 hour. After completion, the organic phase was separated, washed with water (500 mL x 2) dried over Na2S04 and filtered. The solvent was removed under vacuum to give a residue. The residue was purified by column chromatography (Si02, Petroleum ether/Ethyl acetate=40/l to 1/1). The product 1 -benzyl 4-/ert-butyI ( 2R)-2 – (hydroxymethyl)piperazine-l,4-dicarboxylate (85.0 g, 235 mmol, 64% yield, 96% purity) was obtained as a yellow oil. LCMS [ESI, M-99]: 251., 278788-66-2

The synthetic route of 278788-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; MARX, Matthew, Arnold; BLAKE, James, F.; FELL, Jay, Bradford; FISCHER, John, P.; MEJIA, Macedonio, J.; (164 pag.)WO2020/47192; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics