Month: April 2021

5271-27-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.

Example 7 Preparation of Piperazine Derivative To 11 ml of dimethylformamide were added 5.51 g (31.3 mmol) of 1-methyl-3-phenylpiperazine obtained in Example 6, 4.47 g (31.3 mmol) of 2-chloro-3-cyanopyridine, 4.1 g (31.3 mmol) of triethylamine and 5.20 g (31.3 mmol) of potassium iodide, and the resulting mixture was reacted at 125 to 130 C. for 24 hours in nitrogen gas atmosphere. Next, triethylamine and dimethylformamide were distilled off from the reaction mixture under reduced pressure, and thereafter 20 ml of water and 25 ml of ethyl acetate were added to the resulting mixture. The pH of the reaction mixture was adjusted to 8 to 9 with a 10% aqueous sodium hydroxide. The mixture was allowed to separate into two layers. Thereafter, the aqueous layer was extracted twice with 30 ml of ethyl acetate, and the organic layers were combined together. The combined organic layer was washed with 5% aqueous sodium hydrogencarbonate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was crystallized from petroleum ether, to give 3.14 g of pale yellow 2-(4-methyl-2-phenylpiperazin-1-yl)-3-cyanopyridine (yield based on 1-methyl-3-phenylpiperazine: 36%, melting point: 65.7 to 66.8 C.). Its HPLC purity was 97.1%.

5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sumika Fine Chemicals Co., Ltd.; US6495685; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.

A suspension of />-iodo-aniline (918mg, 4.8mmol), 3-oxo-piperazine-l-carboxylic acid tert-butyl ester (960mg, 4.2mmol) (7R,2R)-cyclohexane-l,2-diamine (0.05mL, 0.42mmol), copper (I) iodide (14.9mg,0.0042mmol) and K2CO3 (1.19g, 2.04mmol) in dioxane (4mL), is purged with nitrogen for 5 min in a reaction tube. The tube is sealed and the reaction mixture is heated at 1190C for 15 hours. After cooling to room temperature, the reaction mixture is filtered through a silica cartridge washing with ethyl acetate (4OmL). The filtrate is concentrated in vacuo to afford the title compound as a brown liquid (1.06g, 87%). LCMS: Rt 0.88min (91%)., 76003-29-7

The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,13889-98-0

To a 500 mL round bottom flask with a mechanical stirrer, temperature probe and under a nitrogen atmosphere was added N-acetylpiperazine (10 g, 80 mmol), DMF (150 mL), K2CO3 (16.6 g, 120 mmol) and 4-fluorobenzaldehyde (9.9 g, 80 mmol). The reaction mixture was heated to 100 C. for 20 hours. Followed the reaction by TLC monitoring the aldehyde consumption (Conditions: 20% EtOAc/hexane). After the reaction was complete water (150 mL) was added and cooled to room temperature. Extracted with MTBE (200 mL) and then EtOAc (200 mL). Concentrated the organic layer on the rotovap to yield the product.

As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.

Reference£º
Patent; Milliken & Company; Valenti, Dominick J.; Dey, Sanjeev K.; Qin, Haihu; Freund, Wesley A.; Miracle, Gregory S.; (24 pag.)US2019/112488; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13484-40-7, 1-(2-Methoxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 7, 8 or 9 (0.74-0.91 mmol) in 3 mL of n-BuOH kept in a PV with stirring, cyclic amines (1.12 mmol) was added. The sealed PV was placed in an oil bath at 145-150 C and stirred for 30-40 min. n-BuOH was evaporated in vacuo and the residue was re-dissolved in 3:1 EtOAc/DCM and washed successively with saturated NaHCO3 and NaCl solution (1 ¡Á 15 mL), respectively. The aqueous layer was washed with EtOAc (3 ¡Á 5 mL) and the organic layer was dried over anhydrous MgSO4 then filtered. The solution was evaporated in vacuo to afford either solid or semisolid product. Some physical and spectroscopy data are provided below for 7a-r, 8a-f, 9a-e.

13484-40-7, As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.

Reference£º
Article; Mohamed, Tarek; Zhao, Xiaobei; Habib, Lila K.; Yang, Jerry; Rao, Praveen P.N.; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2269 – 2281;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20327-23-5, A mixture of the chloropyrimidine (200 mg, 0.38 mmol), the piperazine (238 mg, 1.88 mmol) and N,N-diisopropylethylamine (0.26 mL, 1.51 mmol) in DMSO (1.5 mL) was heated in a sealed tube at 110 C for 2 h. The reaction was cooled to room temperature and diluted with water. The layer was then extracted with EtOAc (x2). The combined organic layers were washed with water and brine, dried over MgS04, filtered and concentrated to leave a residue which was used purified by column chromatography (Si02; elution with 2:1 hexane:EtOAc) to yield the desired adduct. LCMS 621 [M+H]+.

As the paragraph descriping shows that 20327-23-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; BASU, Kallol; DEMONG, Duane; SCOTT, Jack; LI, Wei; HARRIS, Joel; STAMFORD, Andrew; POIRIER, Marc; TEMPEST, Paul; WO2014/137719; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

149057-19-2, 4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 587a (25 g, 69 mmol) in EtOH (50 mL) was added HCl.EtOH (35%, 50 mL). The mixture was stirred at 25 C. for 4 hours. The mixture was evaporated to afford product as white solid (18 g, 100%). MS (ESI): mass calcd. for C13H16N2O4 264.11, m/z found 265.1 [M+H]+., 149057-19-2

The synthetic route of 149057-19-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VenatoRx Pharmaceuticals, Inc.; BURNS, Christopher J.; COBURN, Glen; LIU, Bin; YAO, Jiangchao; BENETATOS, Christopher; BOYD, Steven A.; CONDON, Stephen M.; HAIMOWITZ, Thomas; US2019/375708; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.,70261-82-4

General procedure: To a solution of 2 (0.3 g, 0.68 mmol), HATU (0.26 g, 0.68 mmol)and DIPEA (0.24 mL, 1.36 mmol) in dry CH2Cl2 (10 mL) were stirred for20 min at room temperature, the substituted anilines or benzylamines (0.68 mmol) was added slowly. The reaction mixture was stirred for 5 hat room temperature. The resulting mixture was diluted by H2O(10 mL), and extracted by EtOAc (3¡Á10 mL). The combined organiclayers were washed with brine and dried over anhydrous MgSO4, filtered,and concentrated under reduced pressure. The residue was recrystallized from the solution of MeOH-H2O (1:1) to give the amides3a-n in good yields of 80.2-88.5%.

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Article; Qiu, Yinda; Xiao, Zhongxiang; Wang, Yanyan; Zhang, Dingfang; Zhang, Wenxin; Wang, Guangbao; Chen, Wenbin; Liang, Guang; Li, Xiaokun; Zhang, Yali; Liu, Zhiguo; Bioorganic and Medicinal Chemistry; vol. 27; 20; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

162046-66-4, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4- (4-t-butoxycarbonylpiperazin-1-yl) benzoic acid (1.0 g, 3.3 mmol) and 1- (t-butoxycarbonylamino)-2-aminobenzene (Method 17,0. 68 g, 3.3 mmol) in DMF (10 ml) was added 4- (4, 6-dimethoxy-1, 3, 5-triazinyl-2-yl)-4-methylmorpholinium chloride (1. 1 g, 4.0 mmol) (Method 18). The mixture was stirred at ambient temperature for 20 hours. The mixture was concentrated itt vacuo and the residue partitioned between water and ethyl acetate. The organic phase was separated and the aqueous reextracted with ethyl acetate. The combined organic extracts were dried over magnesium sulfate and evaporated. The residue was purified by flash chromatography (eluting with 4: 1-1: 1 isohexane/ethyl acetate). The product was dissolved in 1,4-dioxane (2.5 ml) and treated with a 4M solution of hydrogen chloride in 1,4-dioxane (2.5 ml). The mixture was stirred at ambient temperature for 4 hours. The resulting solid was collected by filtration, trated with a 2M aqueous solution of sodium hydroxide and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate to afford the title compound as a colourless solid (176 mg, 92%); NMR Spectrum : (DMSO-d6) 2.89 (t, 4H), 3.25 (t, 4H), 4.90 (s, 2H), 6.66 (t, 1H), 6.84 (d, 1H), 7.01 (m, 3H), 7.21 (d, 1H), 7.92 (d, 2H), 9.48 (s, 1H) ; Mass Spectrum : M+H 297., 162046-66-4

The synthetic route of 162046-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/87057; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

692058-21-2,692058-21-2, 1-Boc-4-(2,2,2-trifluoroethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(lH-Indazol-4-yl)-4-mophiholin-4-yl-6-[4-(2,2,2-trifluoro-ethyl’)-piperazin-l- ylmethyl]-thieno[3,2-dlpyrimidine (90).Prepared via 2-Chloro-4-morpholin-4-yl-6-[4-(2,2,2-trifluoro-ethyl)- piperazin-l-ylmethyl]-thieno[3,2-d]pyrimidine, prepared from l-(2,2,2-trifluoro- ethyl)-piperazine.Amine preparation: to BOC-piperazine (4g) in DCM (4OmL) was added trifluoroacetic anhydride (6.06mL) and triethylamine (3.29mL). After stirring overnight the reaction mixture was diluted with diluted with DCM, washed with sodium bicarbonate solution, dried (MgSO4) and the solvent removed in vacuo to yield 4-(2,2,2-trifluoro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester (6.06g).To 4-(2,2,2-trifluoro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester (6.06g) in dry THF (6OmL) was added borane dimethyl sulfide complex (4.5ml) and EPO the reaction mixture was heated to reflux. After 2 h the reaction mixture was cooled to O0C and MeOH was carefully added, followed by water. The organics were extracted into ethyl acetate, dried (MgSO4) and the solvent removed in vacuo to yield 4-(2,2,2-trifluoro-ethyl)-piperazine-l-carboxylic acid tert-butyl ester (4.46g). Treatment with HCl in DCM/MeOH yielded the desired compound, which was isolated as the hydrochloride salt.1H NMR (400MHz, CDCl3): 2.56 (4H, m), 2.69 (4H, m), 2.93 (2H, q), 3.79 (2H, s), 3.85 (4H, m), 4.02 (4H, m), 7.23 (IH, s), 7.44 (IH, d), 7.52 (IH, d), 8.21 (IH, d), 8.94 (IH, s).

As the paragraph descriping shows that 692058-21-2 is playing an increasingly important role.

Reference£º
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, General procedure: 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoic acid (8.95g, 31mmol) was stirred in a solvent of 58 dimethyl formamide (25mL).The reaction solution was added with 59 HATU (12.98g, 34.1mmol), 72 DIPEA (10.26mL, 62.0mmol) and 104 3-(trifluoromethyl)aniline (5g, 31mmol), followed by stirring for about 8h at room temperature. The reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting mixture was concentrated to give the crude 132 product, which was purified by silica gel column chromatography.

The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Qi; Dai, Yang; Ji, Yinchun; Shi, Huanyu; Guo, Zuhao; Chen, Danqi; Chen, Yuelei; Peng, Xia; Gao, Yinglei; Wang, Xin; Chen, Lin; Jiang, Yuchen; Geng, Meiyu; Shen, Jingkang; Ai, Jing; Xiong, Bing; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 671 – 689;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics