Month: April 2021

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2?chloro?5?nitrobenzaldehyde (2 g, 10.8 mmol), 1?isopropylpiperazine (2.07 g, 16.2 mmol) and potassium carbonate (2.68 g, 19.4 mmol) in DMF (10 mL) was heated at 90 ¡ãC for 4 h. The reaction mixture wascooled to room temperature and diluted with water. The resulting precipitate was collected by filtration, then washed on the filter with water and dried in a vacuum oven to give the title compound (2.8 g, 96percent) . LCMS (Method A) : = 0.49 mi m/z = 278 [M+H].

4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

84477-85-0, Benzyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 17 4-[4-Benzyloxycarbonyl-2-methyl-1-piperazinyl]-2-trifluoromethylbenzonitrile A 1.01 g portion of benzyl 3-methylpiperazine-1-carboxylate synthesised in Reference Example 10, 814 mg of 4-fluoro-2-trifluoromethylbenzonitrile and 2.38 g of potassium carbonate were added to 20 ml of DMF and stirred at 100C for 20 hours. This was mixed with water, extracted with ethyl acetate and dried, and then the solvent was evaporated. The resulting residue was purified by a silica gel column chromatography to obtain 440 mg of the title compound from ethyl acetate-hexane (3:1, v/v) elude.

84477-85-0, The synthetic route of 84477-85-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1122242; (2001); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

A solution of 2.2 mMol 6-(6-chloropyrimidin-4-yloxy)-naphthalene-1-carbonyl chloride (Step19.3) in 15 ml CH2CI2 is added to a stirred solution of 410 mg (2.0 mMol) 4-(4-methyl- piperazin-1-ylmethyl)-phenylamine and 680 mul (4.0 mMol) diisopropylethylamine in 15 mlCH2CI2. After 30 min, the reaction mixture is poured into a mixture of NaHCO3 and CH2CI2.The aq. phase is separated off and extracted with CH2CI2. The combined organic layers are washed with water and brine, dried (Na2SO4) and concentrated to give the crude product which is purified by column chromatography (SiO2; CH2CI2/Et0H/NH395:4.5:0.5) to afford the title compound as a yellow powder., 70261-82-4

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/104538; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

928025-56-3,928025-56-3, (S)-tert-Butyl 3-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 9 (0.99 g, 5.4 mmol) was suspended in phosphorus oxychloride (15.2 mL, 163.4 mmol) and N,N-dimethylaniline (0.34 mL, 2.72 mmol) was added. The mixture was heated at 105C (reflux) for 3 h. The resulting yellow-green solution was cooled to r.t. and concentrated in vacuo. The residue was azeotroped with toluene (2 x 50 mL) and dried thoroughly. The resulting yellow-green gum was dissolved in THF (40 mL) and the mixture was cooled to 0C. DIPEA (7.81 mL, 44.85 mmol) was added, followed by tert-butyl (3S)-3-ethylpiperazine-l-carboxylate (1.08 g, 5.38 mmol), then the mixture was stirred at r.t. for 2 h. The mixture was evaporated to dryness, reconstituted in EtOAc (100 mL) and washed with saturated aqueous sodium bicarbonate solution (100 mL) followed by brine (100 mL), then dried (sodium sulfate), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (Isolera 4, SNAP 100 g), using 0-50% TBME in heptane as eluent, to yield the title compound (8.26 g, 78%) as a yellow oil. LCMS (ES+) [M+H]+ 379, RT 1.64 minutes (method 3).

The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HORSLEY Helen Tracey; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193169; A1; (2015);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,75336-86-6

Example 43.1: 2-((R)-3-Methyl-piperazin-l -yl)-nicotinonitrile. A mixture of (R)-2-methyl piperazine (507 mg, 5.06 mmol), 2-chloro-nicotinonitrile (1.05 g, 7.6 mmol), triethylaniine (2 mL, 14.3 mmol) and tetrahydrofuran (8 mL) was heated at 80¡ã C overnight. The reaction mixture was cooled to room temperature and aqueous saturated sodium bicarbonate (75 mL) was added. The mixture was extracted with dichloromethane (3×200 mL) and the combined organic layer washed with water (75 mL), washed with brine (75 mL), dried over sodium sulfate, filtered and concentrated. The residue was purified on silica gel using dichloromethane: 2M ammonia in methanol (95:5) to give 2- ((R)-3-methyl-piperazin-l-yl)-nicotinonitrile (964 mg, 94 percent). 1H NMR (300 MHz, CDCl3): delta(ppm) 8.34 (dd, IH), 7.77 (dd, IH), 6.74 (m, IH), 4.27 (m, 2H), 3.08 (m, 4H), 2.70 (m, IH), 1.15 (d, 3H).

The synthetic route of 75336-86-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2008/112440; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

70261-82-4, A solution [CONTAINING-50%] of propylphosphonic anhydride in N, N-dimethylformamide (Fluka, Buchs, Switzerland; 875 [UL, ~1.] 5 [MMOL)] is added within 20 minutes to a stirred mixture of 4- [METHYL-3- [ [4- (3-PYRIDINYL)-2-PYRIMIDINYL] AMINO]-BENZOIC] acid (306 mg, 1.0 [MMOL),] [4- [ (4-METHYL-] 1-piperazinyl) methyl] benzeneamine (Chem. Abstr. Reg. Number: 70261-82-4; 205 mg, 1.0 [MMOL)] and triethylamine (830 [ZL,] 6.0 [MMOL)] in 8 mL [N, N-DIMETHYLFORMAMIDE.] After stirring for 24 hours at room temperature, the mixture is treated with a saturated aqueous ammonium chloride and extracted three times with ethyl acetate. The solvent is evaporated off under reduced pressure and the residue dried in vacuo. The crude product is crystallised from ethanol-ethyl acetate to give the title compound as a crystalline solid, m. p. [153-155C.]

As the paragraph descriping shows that 70261-82-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/5281; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

655225-01-7, tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

655225-01-7, 0.341 g of 60percent NaH in oil is added to a solution of 0.748 g of N-methylacetamide in 80 ml of THF and stirred for 10 minutes at RT. Then 2 g of tert-butyl 4-(2-bromoethyl)piperazinecarboxylate is added and stirred for 16 hours at RT. Water is added to the reaction mixture, it is decanted and the organic solvent is evaporated under vacuum. The residue is dissolved in DCM, filtered through a Chem Elut.(R). cartridge, eluting with DCM and the solvents are evaporated under vacuum. The residue is purified by preparative HPLC and a white solid is obtained.

As the paragraph descriping shows that 655225-01-7 is playing an increasingly important role.

Reference£º
Patent; SANOFI; US2012/277205; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52385-79-2,2-(3-Chlorophenyl)piperazine,as a common compound, the synthetic route is as follows.

52385-79-2, Example 300: 3-ri-(ethylsulfonv0-4-piperidinyl1-5-r3-(2-piperazinv0phenv?-1H- indole-7-carboxamide trifluoroacetate; EPO To a solution of 3-[1 -(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-1 /-/-indole-7-carboxamide (60 mg, 0.13 mmol) in dioxane (1.5 ml_) and water (0.5 ml_) was added 2-(3-chlorophenyl)piperazine (63.7 mg, 0.325 mmol) and potassium carbonate (90 mg, 0.650 mmol). This mixture was degassed for 5 min then tetrakis(triphenylphosphine)palladium(0) (12 mg, 0.011 mmol) was added. The resulting mixture was reacted in a microwave for 30 min at 160 C. The solid was filtered off and all solvents were evaporated. The resulting solution was re-dissolved in dichloromethane and separator was used to remove water. The mixture was concentrated to give organic solvent and then purified by Gilson Preparatory HPLC to give 21.7 mg of the title compound (27.4%). LC/MS = m/z 496.4 [M+H] Ret. Time: 1.28 min.

The synthetic route of 52385-79-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/5534; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

154590-35-9, tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the product of Step 3 (1.00 g, 3.3 mmol) and DIPEA (0.88 ml, 5.1 mmol) in CH2Cl2 (15 ml) add trifluoroacetic anhydride (0.57 ml, 4.1 mmol). Stir 2 h and add a second portion each of DIPEA and anhydride. Stir 1 h and wash with satd. NaHCO3, then water. Dry (MgSO4) and concentrate to obtain the amide as a yellow solid., 154590-35-9

154590-35-9 tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 16203630, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Corporation; US2005/239795; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-Bromomethyl-benzenesulfonyl chloride (2.6 g, 9.65 mmol, 1.0 equiv.) and 1-(4-Trifluoromethyl-phenyl)-piperazine (2.2 g, 9.7 mmol, 1.0 equiv.) in THF (20 mL) was added Et3N (1.34 mL, 9.65 mmol, 1.0 equiv.). The resulting mixture was stirred at room temperature for 3 h and then diluted with ethyl acetate (100 mL). The diluted mixture was washed with water (2¡Á50 mL), brine and dried over Na2SO4. After removal of solvent, the crude product was purified by chromatography to give 4.08 g of desired product (99%). 1H NMR (400 MHz, CDCl3), delta (ppm): 7.81 (t, 1H), 7.71 (dt, 1H), 7.65 (d, 1H), 7.55 (t, 1H), 7.47 (d, 2H), 6.88 (d, 2H), 4.53 (s, 2H), 3.35 (m, 4H), 3.19 (m, 4H).

30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics