Month: April 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of (+/-)-tert-butyl 3-methylpiperazine-1-carboxylate (1.5 g), 1-fluoro-4-nitrobenzene (1.06 g) and potassium carbonate (2.07 g) in dimethyl sulfoxide (15 ml) was stirred at 120 C. for 15 hours. The reaction mixture was cooled to room temperature and poured into water (30 ml). The mixture was extracted with ethyl acetate three times. The combined organic layers were washed successively with water (twice) and brine, and dried over magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate 2:1) to give the title compound as a white solid. [00322] 1H-NMR (300 MHz, CDCl3) delta 1.18 (d, J=5 Hz, 3H), 1.48 (s, 9H), 2.99-3.31 (m, 3H), 3.55 (td, J=2 Hz,9 Hz, 1H), 3.85-4.26 (m, 3H), 6.76 (d, J=8 Hz, 2H), 8.12 (d, J=8 Hz, 2H)., 120737-59-9

As the paragraph descriping shows that 120737-59-9 is playing an increasingly important role.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6825200; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1001180-21-7,(R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

(R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-l-carboxylate (1.0 g, 3.0 mmol, see Example 3) was dissolved in DCM (15 mL) in a plastic bottle, and then DAST was added neat over approximately 5 minutes. The reaction was quenched after 42 hours at room temperature by pouring into saturated aqueous sodium bicarbonate solution mixed with ice. The organic layer was diluted with EtOAc, washed 3 times with water, once with brine and then dried over sodium sulfate. After filtration, the residue was concentrated and purified via column chromatography (70:30 hexane/ethyl acetate, then 1:1 hexane/ethyl acetate) to give (R)-tert-butyl 4-(7,7-difluoro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4- yl)piperazine-l-carboxylate (300 mg, 28%).

1001180-21-7, As the paragraph descriping shows that 1001180-21-7 is playing an increasingly important role.

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; WO2009/6567; (2009); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

The above product 17C (460 mg, 1.66 mM) was dissolved in dichloromethane (10 mL), triethylamine (347 muL, 2.49 mM) and p-toluenesulfonyl chloride (317 mg, 1.66 mM) were added and reacted overnight. The reaction was monitored by TLC, and 5% citric acid aqueous solution was added, extracted with dichloromethane, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and subjected to column chromatography (petroleum ether/ethyl acetate=2/1) to obtain 17D ( 600 mg, yield 84%)., 170911-92-9

The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chengdu Beisikairui Biological Technology Co., Ltd.; Li Dequn; (44 pag.)CN107540636; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

1-fluoro-4-nitrobenzene (1.056 g, 7.49 mmol) and potassium carbonate (3.10 g, 22.5 mmol) were suspended in anhydrous DMF (10 mL) . (R)-tert-butyl 3- (hydroxymethyl)piperazine-1-carboxylate (1.70 g, 7.86 mmol) was added and the mixture was heated at 90 C for21 h. After cooling the mixture was partitioned between brine/water (100 mL) and ethyl acetate (25 mL) . The aqueous layer was separated and further extracted with ethyl acetate (3 x 25 mL) . The combined ethyl acetate fractions were washed with brine/water (1:1, 4 x 25 mL),dried (Na2504), filtered and reduced in vacuo. The resulting residue was purified by silica gel chromatography (gradient 20-100% ethyl acetate in cyclohexane) to afford the title compound (0.69 g, 27.3LCMS (Method C) : = 1.38 mi m/z = 338 [M+H]., 278788-66-2

As the paragraph descriping shows that 278788-66-2 is playing an increasingly important role.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method 1 1-(t-Butoxycarbonyl)-3-methylpiperazine To a cold (-5 C.) solution of 2-methylpiperazine (5.00 g, 0.05 mole) in 200 mL of CH2Cl2 under Ar was added a solution of di-t-butyl dicarbonate (10.9 g, 0.05 mole) in 100 mL of CH2Cl2 over 1 h. The resulting mixture was stirred at -5 C. for 1 h and then at r.t. for 2 h. The solution was then washed (H2O), dried (Na2SO4) and evaporated to give an oil which was chromatographed (SiO2/ethyl acetate then ethyl acetate-MeOH-NH4OH 10:1:0.1) to give the product (4.30 g, 43%) as an oil. This material was used without further purification: 1H nmr (200 MHz, CDCl3) delta4.15-3.75 (br s, 2H), 3.0-2.6 (m, 4H), 2.47-2.35 (m, 1H), 1.48 (s, 9H), 1.08 (d, J=6.7 Hz, 3H)., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fabre-Kramer Pharmaceuticals, Inc.; US2009/281114; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compound 9a-9j were synthesized according to the procedure previously described.8 The above mixture (containing 8) was added a solution of amines (0.56 mmol) in dichloromethane (2 mL) in an ice bath. The reaction mixture was stirred overnight at room temperature, then added dropwise with saturated sodium bicarbonate solution in an ice bath, and the solution was extracted with dichloromethane (20 mL*3). The combined organic layer was dried over anhydrous NaSO4, and then concentrated to afford the crude product, which was further purified using chromatography on silica gel ( Petroleum ether / EtOAc) to obtain the products 9a-9j., 30459-17-7

The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Shu; Li, Gongming; Yang, Xiaohong; Meng, Qian; Yuan, Shuo; He, Yun; Sun, Dequn; Bioorganic and Medicinal Chemistry Letters; vol. 28; 13; (2018); p. 2275 – 2278;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8

4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylaniline(2.27 g, 8.3mmol) was added to the reaction vessel, (10 mmol), 15 ml of tetrahydrofuran, and 10 ml of triethylamine were added thereto, followed by stirring at room temperature for 4 hours. The solution was washed with saturated NaHC03 solution, extracted with ethyl acetate and water, and dissolved with saturated NaCl , Dried over anhydrous Na2S04, and the solvent was removed by distillation under reduced pressure. The residue was purified on a silica gel column to give the title compound as a yellow oil

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NANJING SHENGHE PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; LIU, YANG; ZHANG, JINGZHONG; WANG, DEZHONG; GAO, YIPING; CHEN, HONGYAN; ZHANG, CANG; ZHANG, DI; (68 pag.)TWI523856; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184042-60-2,1-(2-Fluoroethyl)piperazine hydrochloride,as a common compound, the synthetic route is as follows.

To a mixture of 5′-chloro-7′-oxo-7′,8′-dihydro-6’H-spiro[cyclohexane-l,9′-furo[2,3- |quinazoline]-2′-carboxylic acid (Intermediate 15, 50 mg, 0.15 mmol) and l-(2-fluoroethyl) piperazine hydrochloride in DMF (5 mL) was added a solution of N-ethyl-N-isopropylpropan-2- amine (0.08 mL, 0.45 mmol) and 2-(3H-[l,2,3]triazolo[4,5- ?]pyridin-3-yl)- l, 1,3,3- tetramethylisouronium hexafluorophosphate (HATU, 68 mg, 0.18 mmol) in DMF (1 mL). The vial was sealed and the reaction mixture was stirred at room temperature for 3.5 h. The reaction mixture was diluted with water and EtOAc. A precipitate formed in the biphasic mixture, which was filtered, rinsed with H2O and dried under vacuum to give the title compound as a white solid (19 mg, 28%). NMR (400 MHz, DMSO-d6) delta 8.42 (s, 1H), 7.75 (s, 1H), 7.37 (s, 1H), 7.34 (s, 1H), 4.67 – 4.47 (m, 2H), 3.70 (br s, 4H), 2.77 – 2.63 (m, 2H), 2.59 – 2.54 (m, 4H), 2.36 – 2.25 (m, 2H), 1.95 – 1.81 (m, 4H), 1.72 (d, / = 12.7 Hz, 1H), 1.56 (d, / = 14.2 Hz, 2H), 1.35 – 1.22 (m, 1H). [M+H] = 449.0., 184042-60-2

As the paragraph descriping shows that 184042-60-2 is playing an increasingly important role.

Reference£º
Patent; DART NEUROSCIENCE, LLC; SANTORA, Vincent, John; CHEN, Mi; CHUNG, DeMichael; (377 pag.)WO2019/14305; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a sealed tube, 2- (2, 8-dimethylimidazo [1 ,2-b]pyridazin-6-yl)-7-fluoro-9-methyl- pyrido[1,2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol) and (S)-2-methylpiperazine (62 mg, 0.6 19 mmol, 4.0 eq.) were stuffed in DMSO (2 mL) at 125C overnight. The solvent was removed under high vacuum. The residue was taken up in CH2C12 and washed with an aqueoussaturated solution of NaHCO3. The organic layer was separated and dried over Na2SO4 and concentrated in vacuo. The crude was purified by column chromatography (Si02, CH2C12/MeOH=95/5 to 90/10) to afford the title product (45 mg, 72%) as a light yellow solid. MS m/z 404.3 [M+Hi., 74879-18-8

74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALSENZ, Jochem; GRASSMANN, Olaf; KUEHL, Peter; METZGER, Friedrich; MCCARTHY, Kathleen Dorothy; MORAWSKI VIANNA, Eduardo Paulo; WOODHOUSE, Marvin Lloyd; (130 pag.)WO2017/80967; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

Step 3.Synthesis of 4-(4-ethylpiperazinyl)benzeneisothiocyanate To 4-(4-ethylpiperazinyl)phenylamine in acetone at 0 C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq).The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water.The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 4-(4-ethylpiperazinyl)benzeneisothiocyanate. MS: MH+=247.

115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference£º
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics