Month: April 2021

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 0.342 g of 4-(4-ethylpiperazine-1-yl)phenylamine (4d;0.00167 mol) in a dry round bottom flask was added 10 mL 98%ethanol. Then 0.265 g of ethyl 2,4-dioxo-6-methylcyclohexanecarboxylate(E164; previously synthesized in our lab)23 was added. The reactionmixture was refluxed for about 6 h and a total of 5 mL additionalethanol was added. The reaction was monitored by thin layer chromatography(dichloromethane: methanol 85/15). After 6 h, the heatwas turned off and reaction continued to stir at room temperatureovernight. After reaction was completed, the reaction was adsorbed ona silica gel and purified by automated flash chromatography (dichloromethane:methanol 75/25) to yield a yellow semi-solid (54)(0.154 g, 30%).1H NMR (300 MHz, d-CDCl3): delta (ppm) 1.099-1.176 (t,3H), 1.276-1.355 (t, 3H), 1.951 (d, 3H), 2.392-2.547 (q, 2H),2.498-2.641 (t, 4H), 3.211-3.244 (t, 4H), 4.239-4.287 (q, 2H), 5.403(s, 1H), 6.873-6.903 (d, 2H), 7.039-7.069 (d, 2H). HRMS (ESI): m/z,Calcd. for C22H31N3O3 [M+H]+: 386.2433, found 386.2564.

115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.

Reference£º
Article; Ghoneim, Ola M.; Bill, Ashley; Dhuguru, Jyothi; Szollosi, Doreen E.; Edafiogho, Ivan O.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 3890 – 3898;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

4-[(4-methyl-1-piperidinyl) methyl] -3- (trifluoromethyl) -benzeneamine (360 mg, 1.33 mmol),N, N-Diisopropylethylamine (273 muL, 1.60 mmol),Dissolve DMAP (1.2 mg, 0.01 mmol) in THF (5.0 mL),3,5-Dibromo-4-methyl- benzoyl chloride (500 mg, 1.6 mmol) was added and stirred at room temperature for 2 hours.Add water and extract with ethyl acetate,It concentrated under reduced pressure with an evaporator.Silica gel column chromatography of the obtained residueThe compound 3 was purified by (chloroform: methanol = 10: 1).(540.0 mg, 0.98 mmol, 73.8%, pale yellow solid) were obtained., 694499-26-8

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kyoto University; Arkray Corporation; Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Nakanishi, Shuichi; (27 pag.)JP2019/64986; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.314741-39-4,(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

(d) [2S]-4-t-Butoxycarbonyl-2-hydroxymethylpiperazine A solution of Example 1(c) in dry tetrahydrofuran (40 ml) at 0 C. was treated with lithium aluminum hydride (0.50 g) and the mixture was stirred at 0 C. for 1.5 hours. The cooled solution was treated dropwise with a solution of 2M sodium hydroxide until a white precipitate had formed. Dichloromethane and anhydrous sodium sulfate were added and the solution was filtered and evaporated to give a pale yellow oil (3.0 g). MS (+ve ion electrospray) m/z 217 (MH+).

314741-39-4, The synthetic route of 314741-39-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SmithKline Beecham Corporation and SmithKline Beecham p.l.c.; US2003/203917; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

In THF (50 mL) were dissolved 4-((3-chloro-4-methoxybenzyl)amino)-2-(5-azaspiro [2.4]heptan-5-yl)pyrimidine-5-carboxylic acid (1.0 g, 2.58 mmol), tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (709 mg, 3.1 mmol) and HATU (1.18 g, 3.09 mmol). DIEA (1 mL, 5.16mmol) was added. The reaction was conducted at ambient temperature for 8 h. The solvent was removed, and DCM (50 mL) was added for resolution. The DCM phase was washed with water (50 mLx3). The organic phase was dried, concentrated and purified by silica gel column chromatography (DCM / methanol = 150/1) to give tert-butyl 4-(2-(4-((3-chloro-4-methoxybenzyl)amino)-2-(5-azaspiro[2.4]heptan-5-yl) pyrimidine-5-formamido)ethyl)piperazine-1-carboxylate as a white solid (910 mg, 59 percent yield)., 192130-34-0

As the paragraph descriping shows that 192130-34-0 is playing an increasingly important role.

Reference£º
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; WANG, Aichen; EP2886540; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

General procedure: To a 10 ml microwave vial with stir bar was added amine (0.270 g, 1.5 equiv) and DABAL-Me3 (0.540 mg, 1.2 equiv). Reagents were suspended in THF (4 ml) and run in microwave reactor at 130 C for 20 min. The reaction mixture was cooled to room temperature and to it was added the appropriate Intermediate (0.500g. 1 equiv). The reaction mixture was irradiated in microwave reactor at 130 C for 20 min. After allowing to cool down to room temperature the reaction mixture was quenched by the addition of 2M HCl. The reaction mixture was extracted with ethyl acetate. The combined organic layer was washed with water (20 ml) and brine solution then dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude residue was purified by column chromatography using petroleum ether-ethyl acetate as eluents to get the pure amide.

109384-27-2, 109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; SHERER, Brian; BRUGGER, Nadia; WO2015/130905; (2015); A1;,
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55112-42-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

Benzyl N-(4-methylpiperazin-1-ylcarbonyl)glycinate may be prepared in the following manner: 4.2 cm3 of triethylamine and 3.02 g of benzyl glycinate hydrochloride are added, at 20 C., to 3 g of 4-methylpiperazin-1-ylcarbonyl chloride hydrochloride in solution in 150 cm3 of tetrahydrofuran. After stirring for 16 hours at 60 C., the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) and the residue is taken up in 70 cm3 of dichloromethane. The organic phase is successively washed with twice 100 cm3 of a saturated aqueous sodium bicarbonate solution and 70 cm3 of water, and then dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2.7 kPa) to give 1.9 g of benzyl N-(4-methylpiperazin-1-ylcarbonyl)-glycinate in the form of a white solid. 1H NMR spectrum (400 MHz, (CD3)2SO d6, delta in ppm): 2.18 (s: 3H); 2.25 (t, J=5 Hz: 4H); 3.30 (t, J=5 Hz: 4H); 3.80 (d, J=6 Hz: 2H); 5.13 (s: 2H); 7.02 (t, J=6 Hz: 1H); from 7.30 to 7.45 (mt: 5H).

As the paragraph descriping shows that 55112-42-0 is playing an increasingly important role.

Reference£º
Patent; Aventis Pharma S.A.; US6569854; (2003); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2,3-dichloro-1,4-naphthoquinone (0.37 g, 1.60 mmol) and 4-(4- methylpiperazin-1-yl)aniline (0.3 g, 1.46 mmol) was dissolved in EtOH (5 ml). The reaction was stirred and refluxed for 16 h. The residue was purified by flash column over silica gel (dichloromethane: methanol= 29: 1) to afford 77 (0.10 g, 17.30 %).1H NMR (300 MHz, CDCl3): delta 1.15 (t, J = 6.0 Hz, 3H), 2.48 (t, J= 6.0 Hz, 2H), 2.63 (t, J= 6.0 Hz, 4H), 3.26 (t, J= 6.0 Hz, 4H), 6.89 (d, J= 9.0 Hz, 2H), 7.03 (d, J= 8.7 Hz, 2H), 7.65-7.70 (m, 2H), 7.77-7.79 (m, 1H), 8.10- 8.13 (m, 1H), 8.18-8.20 (m, 1H).

115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-ping; PAN, Shiow-lin; (44 pag.)WO2017/20030; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.197638-83-8,1-Boc-4-(4-Formylphenyl)piperazine,as a common compound, the synthetic route is as follows.

Example 7 tert-Butyl 4-(4-(6-bromo-7-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3H- imidazo[4,5-jb]pyridin-2-yl)phenyl)piperazine-1-carboxylateTo a mixture of 5-bromo-4-(4-((5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-3- nitropyridin-2-amine (0.90 g, 0.22 mmol, 1 eq), EtOH (3.8 mL) and DMF (0.52 mL), tert-butyl-4-(4-formylphenyl)tetrahydro-1-(2H)pyrazine carboxylate (0.069 g, 0.24 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.66 mL, 0.66 mmol). The reaction mixture was heated at 85 C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v; 94:6). The title compound was obtained after trituration with diethyl ether as an off-white solid (0.025 g, 15%); 1H-NMR (500Mz, DMSO-Cf6): delta 1.42 (s, 9H, C(CH3J3), 2.59-2.67 (m, 4H, piperazine N(CH2)2), 3.23-3.29 (m, 4H, piperazine N(CH2)2), 3.43-3.52 (m, 4H, piperazine N(CH2)2), 3.60-3.70 (m, 6H), 7.07 (d, J = 9.0 Hz, 2H, ArH, C6H4), 7.70- 7.75 (m, 1 H, py 4-H), 8.13 (d, J = 9.0 Hz, 2H, ArH, C6H4), 8.18 (s, 1 H, imidazo[4,5- jb]pyridine 5-H), 8.45-8.48 (m, 1 H, py 2-H ), 8.50 (d, 1 H, J = 3.0 Hz, py 6-H)1 13.28 (brs, 1 H, imidazo[4,5-iotab]pyridine N-H); LC (Method B) – MS (ESI, m/z) 4.59 min – 651/653 [(M+H)+, Br isotopic pattern]. ESI-HRMS: Found: 651.2200, calculated for C3IH37FBrN8O2 (M+H)+: 651.2201.

197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.

Example 40G ethyl 2-(3-chlorophenoxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoate EXAMPLE 40A (1.2 g), EXAMPLE 40F (1.4 g), and HK2PO4 (0.9 g) were stirred in DMSO (2 mL) at 130 C. for 24 hours. The mixture was diluted with ethyl acetate, washed three times with water, washed with brine, dried, and concentrated. The concentrate was chromatographed on silica gel with 20% ethyl acetate/hexanes.

1228780-72-0, 1228780-72-0 1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine 66713599, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; US2010/184766; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

17.6 g of N- (4-aminophenyl) -N, 4-dimethyl-1-piperazineacetamide was addedMethyl N-acetyl-3- [methoxy (phenyl) methylene] -2-oxoindoline-6-carboxylate19g was added to DMF15 mL and 75 mL of methanol,Reflux reaction 1.5h or more.The reaction solution was added with 9.4 g of N-methylpiperazine,Reaction 1h,Cooling,Filtration to 5 C.Nidanibu products25.1g.250 ml of nidadibugar methanol was recrystallized,The purity of purified nidadipine was 99.58%

262368-30-9, 262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ruiyang Pharmaceutical Co., Ltd.; Miao Dezu; Hu Qingwen; Cong Chao; Wang Hongguang; Yu Zhibo; (9 pag.)CN106748960; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics