Month: April 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

At room temperature, 20 g of yufloxacin and 400 ml of a 18% methanol solution of hydrogen chloride (i.e., methanolic hydrochloric acid) were added to a 1000 ml Erlenmeyer flask, and the material was rapidly dissolved by stirring at room temperature for 10 minutes. The resulting solution was colorless and transparent, the reaction was continued stirring for 30 minutes, filtered, and the precipitated crystals were collected. The resulting crystals were collected under vacuum at 20C. The resulting crystals were collected in the proportion of 1g: 2ml water was dissolved in water and heated to dissolve, filtered, the filtrate was collected and allowed to cool to room temperature, the filtrate was added 1 volume filtrate of acetone, stirred precipitation, the precipitation of crystals collected in 20 C under vacuum drying, the sample gradually turned white to pale yellow solid, that is the present invention is water-soluble, The obtained compounds were characterized by X-ray powder diffractometry, differential scanning calorimetry, nuclear magnetic resonance, and infrared spectroscopy, respectively, and their characterization spectra were shown in FIG. 1 to FIG. 6 as crystal B. FIG., 112984-60-8

112984-60-8 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 124225, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Zhaoke Pharmaceutical (Hefei) Co., Ltd.; Li Xiaoyi; Dai Xiangrong; Zhou Guanqun; (20 pag.)CN107383069; (2017); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-15-1,Methyl 1-Boc-piperazine-2-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of Methyl 1-Boc-piperazine-2-carboxylate (1.837 g, 7.52 mmol), bromobenzene (0.728 ml, 6.84 mmol), Pd2(dba)3 (0.063 g, 0.068 mmol), DavePhos (0.032 g, 0.082 mmol) and Cs2CO3 (3.34 g, 10.25 mmol) in1,4-Dioxane (15 ml, solvent was degassed for 40 min before using) with molecular sieves (4 A) was heated to 85 C and stirred under argon for 24 hrs. After cooling to room temperature, the mixture was filtered through a plug of celite and concentrated to a yellow oil which was purified via flash chromatography (5%EtOAc/Hexanes) to give a yellow viscous liquid Methyl1-Boc-4-phenylpiperazine-2-carboxylate (2 g, 91 % yield)., 129799-15-1

129799-15-1 Methyl 1-Boc-piperazine-2-carboxylate 2756818, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Zhao, Huanyu; Prosser, Anthony R.; Liotta, Dennis C.; Wilson, Lawrence J.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 21; (2015); p. 4950 – 4955;,
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103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,103-76-4

(1) Preparation of 1-tert-butoxycarbonyl-4-(2-hydroxyethyl)piperazine To a solution of 10.00 g of 1-(2-hydroxyethyl)piperazine in 70 mL of dioxane at room temperature was added dropwise a solution of 16.43 g of di-tert-butyl dicarbonate in 30 mL of 1,4-dioxane with stirring. After completion of the reaction, the mixture was concentrated and n-hexane was added to the residue. The solid was collected by filtration and dried to give 14.11 g of the title compound.

The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsui Chemicals, Inc.; US5969138; (1999); A;,
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2762-32-5, Piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Piperazinecarboxylic acid and 2-chloro-l,3-py-rimidine were stirred with triethylamine and MeOH. After stirring overnight at reflux, the mixture was filtered and concentrated in vacuo to give the desired compound which was used directly in Step B (MH+=209).

2762-32-5, As the paragraph descriping shows that 2762-32-5 is playing an increasingly important role.

Reference£º
Patent; Schering Corporation and Pharmacopeia, Inc.; US2004/147559; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.655225-01-7,tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

tert-Butyl 4-(2-((4-chloro-5-iodo-2-methoxyphenyl)amino)ethyl)piperazine-1-carboxylate To a stirred solution of 4-chloro-5-iodo-2-methoxyaniline (968 mg, 3.42 mmol) in anhydrous THF (20 mL) at 0¡ã C., NaH (60percent in mineral oil, 205.2 mg, 5.13 mmol) was added and the resulting mixture was stirred at reflux under nitrogen for 1 h. To this mixture, tert-butyl-4-(2-bromoethyl)piperazine-1-carboxylate (500 mg, 1.71 mmol) was added and the resulting mixture was stirred at room temperature for 15 h. The mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate and brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (10-30percent ethyl acetate/petroleum ether) to afford the desired product (180 mg, 21percent yield) as a solid., 655225-01-7

655225-01-7 tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate 15946441, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao; US2014/288045; (2014); A1;,
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169447-70-5,169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a solution containing 5-fluoro-2-methyl-3-nitrobenzene (D24, 10 g) and (S)-2-methylpiperazine-1-carboxylic acid tert-butyl ester (12.03 g) in DCM (120 mL) was added acetic acid (3.28 g) dropwise. The mixture was stirred at room temperature for one hour. Sodium triacetoxyborohydride (23.15 g) was added to the ice bath. The mixture was stirred overnight at room temperature,The reaction was stopped using saturated NaHC03 solution. The organic layer was dehydrated with anhydrous Na2SO4, filtered, and concentrated in vacuo to give the title compound (22.17 g) as a slurry.

The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; LEI, HUI; MA, XIN; REN, FENG; LIN, XICHEN; MARQUIS, ROBERT W., JR; (139 pag.)TW2017/14884; (2017); A;,
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30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 26 To a solution of Compound B (0.2 g, 0.54 mmol) in acetonitrile (5 mL) at room temperature were added diisopropylethylamine (0.4 mL, 2.3 mmol) and 1-(4-trifluoromethylphenyl)piperazine (0.187 g, 0.81 mmol) and the reaction mixture was heated to 80 C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 565. An NMR spectrum is provided in FIG. 26.Yield: 0.22 g (72%).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
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259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of tert-butyl 3,3-dimethylpiperazine-l-carboxylate (150 mg, 0.700 mmol) in dioxane (2 mL) were added dicyclohexyl(2′,6′-diisopropoxy-[l,l’-biphenyl]-2-yl)phosphine (Ruphos; 65.3 mg, 0.140 mmol) and N-(4-bromophenyl)methanesulfonamide (193 mg, 0.770 mmol), Ruphos Pd G4 (119 mg, 0.140 mmol), sodium tert-butoxide (336 mg, 3.50 mmol) and the resulting mixture was stirred at 65C for 4 h. The mixture was concentrated and the residue was purified via silica gel chromatography (20 – 100 % EtOAc in hexanes) to give tert-butyl 3,3- dimethyl-4-(4-(methylsulfonamido)phenyl)piperazine-l-carboxylate (173 mg, 0.451 mmol, 64 % yield) as a brown amorphous material. MS (ES+) C18H29N3O4S requires: 383, found: 384 [M+H]+.

259808-67-8, As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.

Reference£º
Patent; TESARO, INC.; LEWIS, Richard T.; JONES, Philip; PETROCCHI, Alessia; REYNA, Naphtali; HAMILTON, Matthew; CROSS, Jason; TREMBLAY, Martin; LEONARD, Paul Graham; (216 pag.)WO2018/136887; (2018); A1;,
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923565-99-5,923565-99-5, (R)-1-Cbz-2-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Description 27: Phenylmethyl (2R)-2-methyl-4-({4-[2-(methyloxy)-2-oxoethyl]phenyl}methyl)-1- piperazinecarboxylate (D27). A mixture of D16 (243mg, 1mmol), diisopropylethylamine (174ul, 1mmol) 1,1- dimethylethyl (2R)-2-methyl-1-piperazinecarboxylate (234mg, 1mmol) in DMF was stirred at room temperature for 1 h then allowed to stand overnight. The solvent was removed in vacuo, then the residue was diluted with water (20ml) and extracted with EtOAc (2x20ml). The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give the title compound as a yellow oil (383mg). deltaH (CDCI3, 250MHz) 7.21-7.40 (9H, m), 5.13 (2H, AB) 4.29 (1 H1 m), 3.91 (1 H, m), 3.70 (3H, s), 3.62 (2H, s), 3.43 (2H, m), 3.20 (1 H1 m), 2.78 (1H1 m), 2.62 (1 H1 m), 2.05-2.18 (2H1 m), 1.29 (3H1 d).

The synthetic route of 923565-99-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/12479; (2007); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1403898-64-5,(2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

DIPEA (7.7 ml, 44.2 mmol) was added slowly to a stirred solution of 472 7-bromo-4,6-dichloro-8-methyl-3-nitroquinoline (9.9 g, 29.47 mmol) and 180 tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (8.82 g, 38.31 mmol) in 63 DCM (100 ml) at rt. The resulting solution was stirred at rt for 64 h and then concentrated in vacuo to afford crude product, which was purified by flash silica chromatography (0 to 40% 57 EtOAc in 58 heptane) to give 487 tert-butyl (2R,5R)-4-(7-bromo-6-chloro-8-methyl-3-nitroquinolin-4-yl)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (8.9 g, 57%) as an orange solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.22 (3H, d), 1.45 (9H, s), 2.91 (3H, s), 2.93-3.02 (1H, m), 3.46-3.68 (3H, m), 3.68-3.81 (2H, m), 4.02 (1H, d), 4.22-4.38 (1H, m), 4.62 (1H, t), 8.22 (1H, s), 9.05 (1H, s); m/z: ES+ [M+H]+ 529.2., 1403898-64-5

1403898-64-5 (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate 71003242, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
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