Month: April 2021

74879-18-8, (S)-(+)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) (S)-(+)-3-methyl-1-(2-nitrophenyl)piperazine. To a solution of 2-bromo-1-nitrobenzene (0.6 g, 3.0 mmol) in 1,4-dioxane (15 mL) was added (S)-(+)-2-methylpiperazine (0.5 g, 0.5 mmol) and powdered K2CO3 (15.0 mmol, 1.5 g) and the resulting suspension was heated at reflux for 10 h. After the suspension was cooled, it was filtered through a sintered glass funnel and the solvent was evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (1:1 hexane/EtOAc followed by 4:1 EtOAc/MeOH) to yield (S)-(+)-3-methyl-1-(2-nitrophenyl)-piperazine as an orange oil (0.53 g, 80%).

74879-18-8, The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Synaptic Pharmaceutical Corporation; US6245773; (2001); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

EXAMPLE 7 6-chloro-2-(4-cyclopropyl-1-piperazinyl)-pyrazine hydrochloride Crude N-cyclopropylpiperazine (2.8 g) and 2,6-dichloropyrazine (3.0 g) are combined in 5 ml 2,2,2-trifluoroethanol and the mixture refluxed 4 hours under N2. The mixture is concentrated under vacuum and the residue partitioned between aqueous sodium carbonate and methylene chloride. The combined methylene chloride extracts are extracted with dilute hydrochloric acid which is made basic with sodium hydroxide. The crude base is extracted with methylene chloride and chromatographed on silica gel. Elution with CHCl3 gives fractions containing 2.4 g pure title base which is treated with hydrogen chloride in ethanol-isopropanol to give 2.0 g of the title salt, mp greater than 340 C. with decomposition at 245 C., 20327-23-5

20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US4163849; (1979); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.

5308-25-8, 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene (34 g, 120 mmol) obtained in above was dissolved in dichloromethane (300 mL), followed by stirring. The reaction solution was added with 1-ethylpiperazine (15.97 mL, 126 mmol) and DIPEA (27.2 mL, 156 mmol), followed by further stirring for about 3 hours at room temperature. The reaction mixture was diluted with dichloromethane, and washed with a saturated aqueous solution of sodium bicarbonate and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the title compound (21.7 g, 57%). -NMR Spectrum (300 MHz, DMSO-MS(ESI+, m/z): 318 [M+H]+

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Patent; HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun; WO2013/100632; (2013); A1;,
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Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(2, 4-Difluoro-phenyl)-piperazine (3.3 mmol ; prepared by reacting piperazine with L-BROMO-2, 4-difluorobenzene according to the procedure described in WO 01/92264) was dissolved in 20 mL of THF and 1. 1 eq. OF PROPARGYL bromide was added, followed by [how much?] eq. of anhydrous K2CO3. The reaction mixture was stirred at room temperature for 18 hours. It was then diluted with EtOAc and washed with brine, dried with Na2SO4 and concentrated to afford 1- (2, 4-difluoro-phenyl) -4-prop-2- ynyl-piperazine., 115761-79-0

115761-79-0 1-(2,4-Difluorophenyl)piperazine 2734637, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BIOGEN IDEC MA INC.; WO2004/92172; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.928025-56-3,(S)-tert-Butyl 3-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

928025-56-3, INTERMEDIATE 11 7-[(2S)-2-Ethylpiperazin- 1 -yll-3-methylisoxazolo[4,5 -d]pyrimidin-5-amine dihydrochioride Intermediate 10 (2.70 g, 16 mmol) was slurried in phosphorus oxychioride (33 mL) and DIPEA (5.3 mL) was added. The mixture was heated at reflux for 5 h. Upon cooling, the reaction mixture was concentrated in vacuo. The brown oil was partitioned between EtOAc and water. The organic layer was dried over Na2SO4 and concentrated. The resulting crude brown oil was dissolved in DMF (10 mL) and DIPEA (1.3 mL) wasadded, followed by (S)-tert-butyl 3-ethylpiperazine-1-carboxylate (0.96 g, 4.17 mmol).The reaction mixture was stirred at 70C overnight. The resulting solution wasconcentrated in vacuo, and the residue was purified by silica gel chromatography(gradient 40-100% EtOAc in isohexane). The resulting crude material was dissolved inEtOH, then 4M HC1 in 1,4-dioxane (10 mL) was added. The reaction mixture was stirredfor 2 h, then concentrated in vacuo, to give the title compound (1.0 g, 19% overall) as asticky brown solid. LCMS (ES+) MH 263, RT 0.76 minutes (method 1).

The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORD Daniel James; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193168; A1; (2015);,
Piperazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.

Stage 3: 6-[4-(4-methylpiperazin-1-yl)benzyl]-5H-quinazolino[3,2-a]quinazoline-5,12(61)-dione hydrochlorideA solution of methyl 2-(2-chloro-4-oxoquinazolin-3(4H)-yl)benzoate (170 mg) and [4-(4-methylpiperazin-1-yl)benzyl]amine (200 mg) in a THF/DCM/Et3N mixture (1 mL/1 mL/1 mL) is stirred for 4 days at ambient temperature then water and dichloromethane are added. After decantation and extractions, the combined organic phases are washed with salt water, dried over Na2SO4 then concentrated under reduced pressure at 40 C. Purification by flash chromatography on silica gel (eluent: dichloromethane/methanol 100:0 to 92:8) produces the expected compound in the form of the free base. The corresponding hydrochloride salt is formed by adding a 1N HCl solution in ethyl ether to the solution of the free base in ethyl acetate. The precipitate obtained is filtered and dried in order to produce the expected hydrochloride compound (85 mg, 36% yield from Stage 2).MS/LC: calculated MM=431.2; m/z=432.3 (MH+)NMR (1H, 400 MHz, DMSO-d6): delta2.83 (d, 3H), 3.12 (m, 4H), 3.48 (d, 2H), 3.81 (d, 2H), 5.55 (s, 2H), 6.98 (AB, 2H), 7.55 (m, 3H), 7.66 (m, 2H), 7.90 (m, 2H), 8.25 (AB, 1H), 8.31 (AB, 1H), 9.11 (AB, 1H), 10.75 (s, 1H)., 216144-45-5

216144-45-5 4-(4-Methylpiperazin-1-yl)benzylamine 2776493, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); US2010/144714; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,6-dichloropyridine (1.0 equiv.) in THF (0.3 M) at -78 C under an atmosphere of nitrogen was added LDA (2M in heptanes, 1.7 equiv.) dropwise via an addition funnel. Upon stirring for 30 min at -78 C, tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate in THF (0.9M, 1.3 equiv.) was added dropwise. The reaction was stirred for 30 min, then quenched by the addition of sat. NH4Cl. The mixture was extracted with ethyl acetate and the organics were washed with brine, dried with magnesium sulfate, filtered, and concentrated. The crude material was dissolved in dry toluene (0.17M) and MnO2 (~ 85%, 20 equiv.) was added to the reaction. The solution was heated to reflux for 2 hours. The reaction was filtered through a pad of Celite while hot, and hot ethyl acetate was used to rinse the Celite pad. The filtrate was evaporated under vacuo and the material was purified via silica gel column chromatography eluting with ethyl acetate and hexanes (1:3) to afford the desired product in 51% yield for the two steps. LC/MS: 436.1/438.1, Rt: 3.53 min. H-NMR (300 MHz, CdCl3): 7.71-7.65 (m, 3H), 7.38 (d, J = 7.8, 1H), 6.84 (d, J=9, 2H), 3.61-3.58 (m, 4H), 3.43-3.93 (m, 4H), 1.49 (s, 9H).

197638-83-8, 197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Nishiguchi, Gisele A.; Atallah, Gordana; Bellamacina, Cornelia; Burger, Matthew T.; Ding, Yu; Feucht, Paul H.; Garcia, Pablo D.; Han, Wooseok; Klivansky, Liana; Lindvall, Mika; Bioorganic and Medicinal Chemistry Letters; vol. 21; 21; (2011); p. 6366 – 6369;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

55121-99-8,55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 257Preparation of 1-{4-[3-(1-methylethyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea. To a stirred solution of triphosgene (35 mg, 0.12 mmol) in CH2Cl2 (4 mL) was added 4-(3-isopropyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)aniline (50 mg, 0.14 mmol) at 25 C. The reaction mixture was stirred for 15 min and NEt3 (20 muL, 0.14 mmol) was added. Stirring was continued for 1 h and (4-aminophenyl)(4-methylpiperazin-1-yl)methanone (103 mg, 0.43 mmol) and NEt3 (200 muL, 1.4 mmol) were added and the reaction mixture was stirred for additional 1 hr. The solvents were removed in a N2 stream and the crude mixture was purified by semi-prep-HPLC (NH3-method) to give 1-{4-[3-(1-methylethyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea (43 mg, 39% yield), MS (ESI) m/z 585.4.

55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Wyeth; US2009/181963; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

2815-34-1, trans-2,5-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method 28 (25)-2, 5-Dimethyl-1- (‘4-nitrophenyDpiperazine; 1-Fluoro-4-nitrobenzene (6g, 42. 52mmol) and (2R, 5S)-2, 5-dimethylpiperazine (21.9g, 191. 34mmol) were heated in acetonitrile (20ml) at 100C for 1 lh. The solution was concentrated in vacuo, then the residue was partitioned between DCM and water + sat. sodium hydrogen carbonate. The organic extract was washed with water (4 times), brine, dried and concentrated. Chromatography on silica gel with MeOH : DCM (1: 99 to 5: 95) gave the title compound as an oil which solidified on standing overnight (8.32g, 83%). NMR (400 MHz) 1.08 (d, 3H), 1.16 (d, 3H), 2.55 (dd, 1H), 3. 18 (m, 2H), 3.34 (m, 2H), 3.95 (m, 1H), 6.91 (d, 2H), 8.03 (d, 2H); m/z 236.

2815-34-1, The synthetic route of 2815-34-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/75461; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

502649-29-8, 1-Boc-3-Benzylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

502649-29-8, To a solution of tert-butyl 3-benzylpiperazine-1-carboxylate (300 mg, 1.09 mmol) in DCM (10 mL) was added TEA (330 mg, 0.45 mL, 3.26 mmol) and CbzCl (278 mg, 0.23 mL, 1.63 mmol). After the reaction mixture was then stirred at rt for 2 hrs. The mixture was diluted with water, and extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give crude product which was purified by column chromatography to give a product (368 mg) as an oil. The oil was dissolved in DCM (2 mL), then TFA (124 mg, 84 muL, 1.09 mmol) was added. The reaction mixture was stirred at rt overnight, then concentrated to give a crude compound 77a (385 mg) as an oil which is directly used in next step. MS: calc?d 311 (MH+), measured 311 (MH+).

As the paragraph descriping shows that 502649-29-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIU, Haixia; SHEN, Hong; ZHU, Wei; HU, Taishan; ZHANG, Zhiwei; DEY, Fabian; (91 pag.)WO2020/52738; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics