Month: April 2021

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

i (+-)-N-(2,6-Dimethylphenyl)-2-(3-methylpiperazin-1-yl)acetamide The subtitle compound was prepared from 2-chloro-N-(2,6-dimethylphenyl)acetamide (7 g) and (+-)-2-methyl-piperazine (3.55 g) by the method of Example 15 step (ii) as a white solid. Yield 7 g. MS: ES(+ve) 262(M+1, 100%), 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Meghani, Premji; Bennion, Colin; US2003/13721; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.162046-66-4,4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.

162046-66-4, (3-Pyrrolidin-l-ylphenyl)methylamine (8 g; 0.0408 mol) was dissolved in DCM (50 ml). Et3N (25 ml; 0.178 mol) was added to a stirring solution. l-(l,l-dimethylethyl)-4- (4-carboxyphenyl)-l-piperazinecarboxylic acid ester (10.429 g; 0.034 mol) was added and the mixture was stirred. CH2Cl2 (100 ml) was added and then DECP (11.9 ml; 0.0796 mol) was added. The reaction mixture was stirred for 18 hours. Then the mixture was stirred in a saturated NaHCO3-solution. The organic layer was separated, dried with MgSO4, filtered off, evaporated and co-evaporated with toluene. Yield : 15.815 g of intermediate 51 (99 %).

As the paragraph descriping shows that 162046-66-4 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/148868; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5464-12-0, 1-(2-Hydroxyethyl)-4-methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(4-Methylpiperazin-1-yl)ethyl 4-nitrophenyl carbonate To a stirred solution of 1-(2-hydroxyethyl)piperazine (26.0 g, 0.2 mol) in DMF (200 mL) was added formic acid (752 mL, 0.2 mol) and formaldehyde (16.2 g, 0.2 mol, 37percent solution in water) The reaction mixture was cautiously heated at 100¡ã C. for 2 hours then stirred overnight at room temperature. The solvent was removed in vacuo. This procedure was repeated 3 further times to give ~100 g of product. The crude products were combined and distilled under vacuum to give, at 74¡ã C., 2-(4-methylpiperazin-1-yl)ethanol (51 g, 44percent) as a colourless liquid. Analytical LCMS: (System C, RT=0.70 min), ES+: 145.1 [MH]+. 4-Nitrophenyl chloroformate (9.85 g, 49 mmol) was dissolved in DCM (200 mL), and cooled to 0¡ã C. 2-(4-methylpiperazin-1-yl)ethanol (7.2 g, 50 mmol) and NMM (6 mL) were added, and the reaction mixture was allowed to warm gradually to room temperature over 16 hours. The reaction mixture was washed with 1M aq Na2CO3 solution until the yellow colour extracted into the aqueous layer had disappeared. The organic phase was dried (MgSO4), filtered and concentrated in vacuo to give 2-(4-methylpiperazin-1-yl)ethyl 4-nitrophenyl carbonate (10.7 g, 71percent) as a yellow oil which solidified on standing. Analytical LCMS: purity ~80percent (System C, RT=1.70 min), ES+: 310.4 [MH]+., 5464-12-0

The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biovitrum AB; US2009/281087; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure for 10-(amino)-6,ll-dihydro-5H-indeno[l,2- h]ll,6]naphthyridin-5-one (51): A mixture of 10-bromo compound (50) (94 mg, 0.3 mmol), amine (64 mg, 0.45 mmol), Pd2(dba)3 (5.5 mg, 0.006 mmol), S-X-Phos (7.2 mg, 0.015 mmol), sodium tert-butoxide (72 mg, 0.75 mmol) in DMF (4 ml) was degassed and then purged with nitrogen. The mixture was irradiated under microwave at 130 0C for 20 min. It was concentrated and purified on the silica gel column using 0 to 7% methanol and DCM. The residue obtained was further purified on the reverse phase column to provide final product (51).; 5.3 Examples; The following examples were prepared according to the methods, schemes and experimental described above.; Example 49: 10-(4-(2-methoxyethyl)piperazin-l-yl)-6,ll-dihydro-5H-indeno[l,2- h] [l,6]naphthyridin-5~one; MS: m/z 377.2 (M-H+)., 13484-40-7

The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INOTEK PHARMACEUTICALS CORPORATION; JAGTAP, Prakash; PHAM-HUU, Duy-Phong; COHEN, Frederick; HU, Huiyong; WANG, Xiaojing; WO2010/77663; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-39-4, (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

314741-39-4, To a solution of (S)-1-tert-butyl 3-methyl piperazine-1,3-dicarboxylate (500 mg, 2.05 mmol) in anhydrous dichloromethane (20 mL) at 0 C. was added triethylamine (311 mg 3.1 mmol) and acetyl chloride (0.16 mL, 2.25 mmol). The mixture was stirred for 30 minutes, and then the mixture was diluted with dichloromethane. The organic layer was washed with H2O, dried with MgSO4, filtered and concentrated under reduced pressure to provide the titled compound.

314741-39-4 (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 1501855, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Altenbach, Robert J.; Liu, Huaqing; Clapham, Bruce; Aguirre, Ana L.; Cowart, Marlon; Koenig, John R.; Sarris, Katerina; Scanio, Marc J.; Swinger, Kerren K.; Vasudevan, Anil; Villamil, Clara I.; Woller, Kevin R.; US2015/210720; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5,934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15-chloro-3-(3-fury)-N-[2-(4-methylpiperazin-1-yl)ethyl]-1H-indole-2-carboxamideA DMF solution (340 mL) containing the compound obtained in Production example 1-3 (11.6 g), 2-(4-methylpiperazin-1-yl)ethylamine (7.0 g) and HATU (18.5 g) was ice-cooled to 15¡ã C., and diisopropylethylamine (23.2 mL) was added thereto and the resulting solution was stirred overnight at room temperature.The reaction solution was poured into water (1.5 L), and the mixture was stirred at room temperature for 5 minutes.A precipitate was collected by filtration and washed with water and then dissolved in chloroform (600 mL).The chloroform layer was washed with a saturated aqueous sodium hydrogen carbonate solution and then dried over anhydrous magnesium sulfate.The solvent was distilled off under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=2:1 to 1:3), whereby the title compound (8.8 g) was obtained as a pale yellow solid.1H-NMR (400 MHz, CDCl3, deltappm): 2.30 (3H, s), 2.32-2.50 (8H, m), 2.47 (2H, t, J=5.8 Hz), 3.51 (2H, dt, J=5.8 Hz, 5.8 Hz), 6.63 (1H, dd, J=1.9, 0.9 Hz), 7.03 (1H, br s), 7.25 (1H, m), 7.39 (1H, dd, J=8.8 Hz, 0.6 Hz), 7.49 (1H, m), 7.66 (1H, m), 7.70 (1H, m), 9.78 (1H, s).ESI-MS Found: m/z 387[M+H]+

The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

D. Amination Reaction In one experiment, (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (41.73 g, 94.35 mmol) and triethylamine (88 mL, 630 mmol) were added to a mixture of (R)-2-(1-hydroxycyclohexyl)-2-(3-(trifluoromethoxy)phenyl)acetic acid (20.0 g, 62.9 mmol) and cis-2,6-dimethylpiperazine (7.17 g, 62.9 mmol) in methylene chloride (150 mL) at RT. After stirring for 18 h, the mixture was concentrated in vacuo. The residue was purified by flash chromatography on silica gel (50 to 100percent ethyl acetate in heptane) to afford 1-(3,5-Dimethyl-piperazin-1-yl)-2-(R)-(1-hydroxy-cyclohexyl)-2-(3-trifluoromethoxy-phenyl)-ethanone (24.3g, 93percent).

21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.

Reference£º
Patent; Wyeth; US2007/135449; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

[00171]A mixture of 97 (0.30 g, 0.88 mmol), HBTU (0.50 g, 1.32 mmol), DIPEA (0.23 ml, 1.32 mmol) and DMF (2.5 ml) was stirred for a while, to which was then added 4-(4- ethylpiperazin-1-yl)aniline (0.27 g, 1.32 mmol) at room temperature and the mixture was stirred overnight. The residue was filtered by suction filtration to yield a red product. The residue was filtered without further purification to afford 37 (0.40 g, 85.92 %) as a red solid. 1H-NMR (300 MHz, DMSO-d6): ^1.01 (t, J= 7.2 Hz, 3H), 2.34 (q, J= 7.2 Hz, 2H), 3.07 (br, 4H), 5.01 (s, 2H), 6.89 (d, J= 9.0 Hz, 2H), 7.41 (d, J= 8.1 Hz, 2H), 7.56 (d, J= 9.0 Hz, 2H), 7.74 (t, J= 8.1 Hz, 1H), 7.77-7.88 (m, 3H), 7.95-7.98 (m, 2H), 8.09 (s, 1H), 9.98 (s, 1H).

115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-ping; PAN, Shiow-lin; (102 pag.)WO2017/14788; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[Example 71] 1-[5-(5-Methylpyridin-2-yl)-1-(pyridin-3-yl)-1H-pyrazole-3-carbonyl]-4-methyl-3-oxopiperazine Triethylamine (0.330 mL) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (179 mg) were added at room temperature to a solution of 5-(5-methyl-2-pyridyl)-1-(3-pyridyl)-1H-pyrazole-3-carboxylic acid (0.218 g) obtained from Referential Example 9, 1-methyl-2-piperazinone hydrochloride (176 mg) obtained from Referential Example 15, and 1-hydroxybenzotriazole (143 mg) in N,N-dimethylformamide (15 mL), and the mixture was stirred at room temperature for 15.5 hours. The reaction solvent was evaporated under reduced pressure, and the residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogencarbonate. The aqueous layer was further extracted with ethyl acetate four times. The organic layers were combined, and the combined organic layer was dried over sodium sulfate anhydrate. After a filtration step, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel flash column chromatography (dichloromethane – methanol), to thereby give the title compound (231 mg, 78%) as a solid product. 1H-NMR(400MHz,CDCl3)delta:2.34(3H,s), 3.03(3H,s), 3.46-3.50(2H,m), 4.03-4.07(1H,m), 4.41-4.45(2H,m), 4.85(1H,brs), 7.16-7.20(1H,m), 7.34-7.40(2H,m), 7.52-7.56(1H,m), 7.68-7.83(1H,m), 8.30(1H,s), 8.47(1H,brs), 8.59(1H,brs). ESI-MS m/z:377(M+H)+. Elementary analysis: as C20H20N6O2 Calculated: C,63.82;H,5.36;N,22.33. Found: C,63.65;H,5.28;N,22.24.

109384-27-2, 109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

630125-91-6, A mixture of 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (7, 17.5 mg, 0.06 mmol), triethylamine (0.014 mL, 0.1 mmol), and p-nitrophenyl chloroformate (12.4 mg, 0.06 mmol) in 1,4-dioxane (5 mL) was heated at 60 C for 2 h. A solution of 6a (20 mg, 0.06 mmol) in 1,4-dioxane (5 mL) was slowly added thereto. The reaction mixture was heated at 90 C overnight. The reaction mixture was concentrated under reduced pressure and then partitioned between water (5 mL) and ethyl acetate (5 mL). The organic layer was separated and the aqueous layer was then extracted with ethyl acetate (3 ¡Á 3 mL). The combined organic extracts were washed with brine and dried over anhydrous Na2SO4. After evaporation of the organic solvent, the residue was purified by column chromatography (silica gel, hexane-ethyl acetate 3:1 v/v then switching to hexane-ethyl acetate 1:1 v/v) to yield compound 8g (6.0 mg, 15%).

As the paragraph descriping shows that 630125-91-6 is playing an increasingly important role.

Reference£º
Article; El-Gamal, Mohammed I.; Jung, Myung-Ho; Lee, Woong San; Sim, Taebo; Yoo, Kyung Ho; Oh, Chang-Hyun; European Journal of Medicinal Chemistry; vol. 46; 8; (2011); p. 3218 – 3226;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics