Downstream synthetic route of 1-Cyclopropylpiperazine

20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

20327-23-5, 1-Cyclopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-chloro-5-nitropyridine (200 mg, 1.26 mmol) in DMFF (5.0 mL) were added l-cyclopropylpiperazine (191 mg, 1.57 mmol) and DIPEA (0.54 mF, 3.09 mmol) and the mixture was stirred at 80 C for 5 h. The mixture was cooled to RT and diluted with water. The solid was filtered and washed with pet ether to yield 250 mg of the desired product. JH NMR (400 MHz, DMSO-ESI-MS ( m/z ) 249 (M+H)+.

20327-23-5, The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ICHNOS SCIENCES S.A.; CHAUDHARI, Sachin, Sundarlal; GHARAT, Laxmikant, Atmaram; IYER, Pravin; DHONE, Sachin, Vasantrao; ADIK, Bharat, Gangadhar; WADEKAR, Prashant, Dilip; GOWDA, Nagaraj; BAJPAI, Malini; (233 pag.)WO2020/70331; (2020); A1;,
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