With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
Step B: (3-Hvdroxymethyl-benzorib1thioDhen-5-yl)-(4-isoDroDyl-DiDerazin-1 – vD-methanone; . To a suspension of (5-bromo-benzo[iotab]thiophen-3-yl)-nnethanol (130 mg, 0.53 mmol), 1 -isopropyl-piperazine (205 mg, 1.6 mmol), 1 ,8- diazabicyclo[5.4.0]undec-7-ene (DBU; 244 mg, 1.6 mmol), tBu3PBF4 (15 mg, 0.05 mmol) and trans-di-m-acetatobis[2-(di-o-tolylphosphino)benzyl]di-palladium (II) (Hermann’s catalyst; 25 mg, 0.03 mmol) in THF was added Mo(CO)6 (141 mg, 0.53 mmol) and the reaction mixture was sealed and heated at 125 0C with microwave irradiation for 8 min. The solution was concentrated and the resulting residue was partitioned between EtOAc and 1 N NaOH (25 ml_). The organic layer was washed with brine (250 ml_), dried, and concentrated. The resulting residue was purified by FCC to provide 30 mg (18percent) of the title compound as a colorless oil. MS (ESI): mass calcd. for Ci7H22N2O2S, 318.44; m/z found, 319.2 [M+H]+. 1H NMR (CDCI3): 7.88-7.84 (m, 2H), 7.42 (s, 1 H), 7.39-7.35 (m, 1 H), 4.88 (s, 2H), 3.82 (br s, 2H), 3.46 (br s, 2H), 2.73 (h, J = 6.4, 1 H), 2.51 (br s, 2H), 2.36 (br s, 2H), 1.06 (d, J = 6.4, 6H).
4318-42-7, The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/109333; (2008); A1;,
Piperazine – Wikipedia
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