Big data shows that 5747-48-8 is playing an increasingly important role.
5747-48-8, 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 2; In a reaction vessel, a mixture of 1 l-piperazinyldibenzo[b,fj[l,4]-thiazepine ( 10 Kg), 2- (2-chloroethoxy)ethanol (6.33 kg), sodium carbonate (21.55 kg), 1 kg tetrabutyl ammonium bromide and 0.2 kg sodium iodide was heated in 30 liters of water to about 100 0C. The reaction mixture was maintained at about 100 to 1050C for about 5 hours. EPO Starting l l-piperazinyldibenzo[b,f][l,4]-thiazepine was about 0.3 % by HPLC. Maintained for another 2 hours till the l l-piperazinyldibenzo[b,f][l,4]-thiazepme was about less than 0.08 % by HPLC analysis. The reaction mass was cooled to about 30 0C and aqueous layer extracted with methylenedichloride(100 liters). The organic layer was washed with water and concentrated under reduced pressure. The oily residue was so obtained was suspended in 100 litres of ethanol ( commercial) and 4.1 kg fumaric acid was added. The mixture was stirred for about 4 hours and cooled to about 1O0C. The precipitated quetiapine hemi-fumarate salt was filtered and dried to give 12Kg ( yield 80 % & purity 99.8% by HPLC analysis), 5747-48-8
Big data shows that 5747-48-8 is playing an increasingly important role.
Reference£º
Patent; IPCA LABORATORIES LIMITED; WO2006/77602; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics