With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-60-6,(R)-1-Boc-Piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
(2R)-l-(fc/^-Butoxycarbonyl)-4-isopropyIpiperazine-2-carboxylic acidTo (2i?)-l-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (4.5 g) and Na2CO3 (8.32 g) was added dry EtOH (135 ml) and isopropyl iodide (2.16 ml) and the mixture heated at reflux for 18 hours under argon. The solvent was then removed under reduced pressure, 5percentMeO?/DCM (50 ml) added, the mixture stirred for 1 hour in a stoppered flask, filtered and washed through with DCM (2 x 10ml). The filtrate was applied directly to a 12Og- silica Redisep cartridge and purified using 10-70percent MeOH/DCM. After evaporation, the product was isolated as a white foam (4.50 g), which was used without further purification. 1H NMR (400.132 MHz, DMSO) 0.95 (m, 6H), 1.40 (2x s, 9H), 2.30 (m, 2H), 2.75 (m, 2H), 2.95 (t, IH), 3.12 (t, IH,), 3.70 (m, IH), 4.48 (d, IH), 12.60 (br. s, IH).
278788-60-6, As the paragraph descriping shows that 278788-60-6 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/71952; (2007); A1;,
Piperazine – Wikipedia
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