With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5625-67-2,Piperazin-2-one,as a common compound, the synthetic route is as follows.
A) 3-Oxo-piperazine-l-carboxylic acid tert-butyl ester: Piperazinone (20 g, 0.20 mol) was dissolved in 120 mL iV,iV-dimethylformamide. Di-tert- butyldicarbonate (47.9g, 0.20 mmol) was added in portions. After 5 minutes the product precipitated. The solids formed were filtered and dried and used further in step B.1HNMR (400 MHz, chloroform-das solvent and internal reference) delta(ppm) 1.46 (s, 9H), 3.37 (m, 2H), 3.62 (t, 2H, J = 5.1 Hz), 4.08 (s, 2H)., 5625-67-2
The synthetic route of 5625-67-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2007/8144; (2007); A1;,
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