170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 32 (500 mg, 1.66 mmol) in s-butanol (5 mL) were added tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (498 mg, 1.82 mmol) and TFA (760 mg, 6.64 mmol) at room temperature. The resulting reaction mixture was stirred at 100 C for 12 h. It was then diluted with 10% MeOH in CH2Cl2 (100 mL) and washed with saturated sodium bicarbonate solution. The organic layer was dried over Na2SO4 and concentrated in vacuo. Column chromatography (3% MeOH in CHCl3) to afford 33 (400 mg, 44%) as a pale yellow solid.1H NMR (400 MHz, DMSO-d6) delta ppm 9.56 (s, 1H), 9.40 (s, 1H), 8.45 (d, J = 5.2 Hz, 1H), 7.58 (d, J = 9.2 Hz, 2H), 7.44 (s, 1H), 7.24 (d, J = 5.2, Hz, 1H), 6.95 – 6.88 (m, 3H), 5.45 (s, 1H), 4.58 (d, J = 3.2 Hz, 2H), 3.48 – 3.45 (m, 4H), 3.04 – 3.02 (m, 4H), 2.37 – 2.33 (m, 1H), 1.42 (s, 9H), 1.06 – 1.04 (m, 4H).LC-MS (MeCN, pH 3): [M+H]+ = 542, rt = 1.62 mins, purity = > 95%.
170911-92-9, 170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Large, Jonathan M.; Birchall, Kristian; Bouloc, Nathalie S.; Merritt, Andy T.; Smiljanic-Hurley, Ela; Tsagris, Denise J.; Wheldon, Mary C.; Ansell, Keith H.; Coombs, Peter J.; Kettleborough, Catherine A.; Whalley, David; Stewart, Lindsay B.; Bowyer, Paul W.; Baker, David A.; Osborne, Simon A.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 19; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics