169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1 14 (1.60 g, 6.91 mmol) in toluene (21.1 mL) under an argon atmosphere was added (S)-/eri-butyl 2-methylpiperazine-l -carboxylate (1 15, 1.38 g, 6.91 mmol, AK Scientific, Inc., Union City, CA), sodium teri-butoxide (0.73 g, 7.60 mmol, Sigma-Aldrich), and 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (i.e., “X-Phos,” 0.49 g, 1.04 mmol, Sigma-Aldrich). The mixture was degassed under argon and thentris(dibenzylideneacetone) dipalladium (Pd2(DBA)3, 0.63 g, 0.69 mmol, Sigma-Aldrich) was added to form a reaction mixture. The reaction mixture, heated in an oil bath maintained at temperature within the range of from 80C to 85C, was stirred for 1.5 hours. Thereafter, the mixture was cooled to a temperature of about 25C, poured onto cold water, and extracted with EtOAc. The organic layer was separated, washed with brine, and concentrated to an oil which was chromatographed on a silica gel column eluted with 10:90 EtOAc:hexanes and 20:80 EtOAc:hexanes to provide 1.71 g of 1 16 as a solid (63% yield). NMR (CDC13) delta: 1.25 (3H, d, J=6.80Hz), 1.46 (3H, s), 1.48 (9H, s), 1.53 (3H, s), 2.89 (1H, dt, J=3.29, 13.59Hz), 3.09 ( 1 H, dd, J=3.73, 12.06Hz), 3.23 (1H, dt, J=2.85, 13.59Hz), 3.69 (1H, t, J=7.89Hz), 3.83 (1 H, d, J=12.72Hz), 3.92 (1 H, d, J=13.81Hz), 4.01 (1H, d, J=12.90Hz), 4.27 (1H, t, J=6.14Hz), 4.31 (1H, brs), 5.01 (1H, t, J=7.24Hz), 7.30 (1H, d, J=1.97Hz), 7.95 (1H, s). LC/MS (M+1): m/z = 396.
169447-70-5, As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.
Reference£º
Patent; PURDUE PHARMA L.P.; Shionogi & Co. Ltd.; TAFESSE, Laykea; ANDO, Shigeru; KUROSE, Noriyuki; WO2012/176061; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics