With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27561-62-2,Cyclohexyl(piperazin-1-yl)methanone,as a common compound, the synthetic route is as follows.
TO 4- (3-PIPERIDIN-1-YLPROPOXY) BENZOYL CHLORIDE HYDROCHLORIDE (D3) (0.24g) in DCM (10 ML) was added 1- (CYCLOHEXANECARBONYL)-PIPERAZINE (0.155 g) and diethylaminomethyl polystyrene (3. 2MMOL/G, 0.69g). The mixture was stirred for 16h. The reaction mixture was then loaded directly onto a silica column and eluted with 0-10% MEOH (containing 10% 0.880 ammonia solution) in DCM. The isolated free base was dissolved in DCM (5ML) and treated with 4N HCI/DIOXANE solution (1 ml) with stirring for 10MIN. The reaction was concentrated, and the residue co-evaporated with toluene (3X10M1) and then dried at 50C under high vacuum for 16h to yield the title compound (E57) as a PALE SOLID (0.165G). MS ELECTROSPRAY (+ION) -442 (MH+). 1H NMR 8 (DMSO-D6): 9.71 (S, 1H), 7.39 (d, 2H, J=6.84Hz), 7.00 (d, 2H, J=6.84Hz), 4.10 (m, 2H), 3.47-3. 25 (m, 10H), 3.16 (m, 2H), 2.90 (m, 2H), 2.55 (m, 1H), 2.19 (m, 2H), 1.82-1. 62 (m, 10H), 1.40-1. 16 (m, 6H).
27561-62-2, As the paragraph descriping shows that 27561-62-2 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/37800; (2004); A1;,
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