With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.928025-56-3,(S)-tert-Butyl 3-ethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
928025-56-3, INTERMEDIATE 11 7-[(2S)-2-Ethylpiperazin- 1 -yll-3-methylisoxazolo[4,5 -d]pyrimidin-5-amine dihydrochioride Intermediate 10 (2.70 g, 16 mmol) was slurried in phosphorus oxychioride (33 mL) and DIPEA (5.3 mL) was added. The mixture was heated at reflux for 5 h. Upon cooling, the reaction mixture was concentrated in vacuo. The brown oil was partitioned between EtOAc and water. The organic layer was dried over Na2SO4 and concentrated. The resulting crude brown oil was dissolved in DMF (10 mL) and DIPEA (1.3 mL) wasadded, followed by (S)-tert-butyl 3-ethylpiperazine-1-carboxylate (0.96 g, 4.17 mmol).The reaction mixture was stirred at 70C overnight. The resulting solution wasconcentrated in vacuo, and the residue was purified by silica gel chromatography(gradient 40-100% EtOAc in isohexane). The resulting crude material was dissolved inEtOH, then 4M HC1 in 1,4-dioxane (10 mL) was added. The reaction mixture was stirredfor 2 h, then concentrated in vacuo, to give the title compound (1.0 g, 19% overall) as asticky brown solid. LCMS (ES+) MH 263, RT 0.76 minutes (method 1).
The synthetic route of 928025-56-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FORD Daniel James; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193168; A1; (2015);,
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