197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2,6-dichloropyridine (1.0 equiv.) in THF (0.3 M) at -78 C under an atmosphere of nitrogen was added LDA (2M in heptanes, 1.7 equiv.) dropwise via an addition funnel. Upon stirring for 30 min at -78 C, tert-butyl 4-(4-formylphenyl)piperazine-1-carboxylate in THF (0.9M, 1.3 equiv.) was added dropwise. The reaction was stirred for 30 min, then quenched by the addition of sat. NH4Cl. The mixture was extracted with ethyl acetate and the organics were washed with brine, dried with magnesium sulfate, filtered, and concentrated. The crude material was dissolved in dry toluene (0.17M) and MnO2 (~ 85%, 20 equiv.) was added to the reaction. The solution was heated to reflux for 2 hours. The reaction was filtered through a pad of Celite while hot, and hot ethyl acetate was used to rinse the Celite pad. The filtrate was evaporated under vacuo and the material was purified via silica gel column chromatography eluting with ethyl acetate and hexanes (1:3) to afford the desired product in 51% yield for the two steps. LC/MS: 436.1/438.1, Rt: 3.53 min. H-NMR (300 MHz, CdCl3): 7.71-7.65 (m, 3H), 7.38 (d, J = 7.8, 1H), 6.84 (d, J=9, 2H), 3.61-3.58 (m, 4H), 3.43-3.93 (m, 4H), 1.49 (s, 9H).
197638-83-8, 197638-83-8 1-Boc-4-(4-Formylphenyl)piperazine 2795509, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Nishiguchi, Gisele A.; Atallah, Gordana; Bellamacina, Cornelia; Burger, Matthew T.; Ding, Yu; Feucht, Paul H.; Garcia, Pablo D.; Han, Wooseok; Klivansky, Liana; Lindvall, Mika; Bioorganic and Medicinal Chemistry Letters; vol. 21; 21; (2011); p. 6366 – 6369;,
Piperazine – Wikipedia
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