With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure for 10-(amino)-6,ll-dihydro-5H-indeno[l,2- h]ll,6]naphthyridin-5-one (51): A mixture of 10-bromo compound (50) (94 mg, 0.3 mmol), amine (64 mg, 0.45 mmol), Pd2(dba)3 (5.5 mg, 0.006 mmol), S-X-Phos (7.2 mg, 0.015 mmol), sodium tert-butoxide (72 mg, 0.75 mmol) in DMF (4 ml) was degassed and then purged with nitrogen. The mixture was irradiated under microwave at 130 0C for 20 min. It was concentrated and purified on the silica gel column using 0 to 7% methanol and DCM. The residue obtained was further purified on the reverse phase column to provide final product (51).; 5.3 Examples; The following examples were prepared according to the methods, schemes and experimental described above.; Example 49: 10-(4-(2-methoxyethyl)piperazin-l-yl)-6,ll-dihydro-5H-indeno[l,2- h] [l,6]naphthyridin-5~one; MS: m/z 377.2 (M-H+)., 13484-40-7
The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; INOTEK PHARMACEUTICALS CORPORATION; JAGTAP, Prakash; PHAM-HUU, Duy-Phong; COHEN, Frederick; HU, Huiyong; WANG, Xiaojing; WO2010/77663; (2010); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics