208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 8-[cis-3-hydroxy-5-methylpiperidin-l- yl]quinoxaline-5-carbonitrile (300 mg, 1.01 mmol, 1.0 equiv) in DMF (20.0 mL) was added sodium hydride (804 mg, 33.50 mmol) at room temperature. The resulting mixture was stirred for 20 min at room temperature, and then was added tert-butyl 4-(2-chloroethyl)piperazine-l- carboxylate (788 mg, 3.17 mmol). The reaction mixture was stirred for 16 h at room temperature. When the reaction was done, it was quenched by the addition of water (10 mL). The resulting mixture was extracted with ethyl acetate (30 mL x 3). The organic phases were combined, washed with brine and dried over Na2S04. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with MeOH in DCM (0 % to 40 % gradient) to yield the title compound as a yellow solid (170 mg, 35 %). MS: 481 [M+H]+.
208167-83-3, 208167-83-3 tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate 22106269, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK PATENT GMBH; SHERER, Brian; LAN, Ruoxi; BRUGGER, Nadia; CHEN, Xiaoling; TOURE, Momar; CLEARY, Esther; DESELM, Lizbeth Celeste; WANG, Yanping; (397 pag.)WO2020/25517; (2020); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics