With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
The compound of formula 18 (6.0 g, 42.5 mmol) was added to the reaction flask at room temperature,24 mL of N, N-dimethylacetamide,1-acetylpiperazine 16 (6.5 g, 51.0 mmol)N, N-diisopropylethylamine (7.1 g, 55.3 mmol)90 reaction 4 ~ 5h,TLC monitoring reaction is complete,Down to room temperature,The reaction solution was poured into 180 mL of water,Extracted with ethyl acetate (50 mL x 3)Combined organic layer,Washed with saturated brine,Dried over anhydrous sodium sulfate,The compound of formula 43 (8.8 g) was obtained by steaming,As a pale yellow solid (yield 83.7%).
13889-98-0, The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Gao Yong; Ren Jing; Wang Qinglin; Wang Zhao; (67 pag.)CN106905245; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics