Downstream synthetic route of 55112-42-0

As the paragraph descriping shows that 55112-42-0 is playing an increasingly important role.

55112-42-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

Example 2: Preparation of Zopiclone in iso-Butyl acetate[0065] To a slurry of l-chlorocarbonyl-4-methyl piperazine hydrochloride(CMP) (52.96g) in iso-Butyl acetate (500 ml) were added Et3N (46.12g), DMAP (4.62g) and 7-OH-Py (5Og). The slurry was heated to 8O0C and the heating was maintained for about 5.5 h. After about 2h at 800C, 100 ml iso-Butyl acetate was added to the slurry. After the reaction completion (5.5 h, heating), the reaction was stopped and the slurry was cooled to the room temperature. Water (600ml) was added to the reaction mixture and the slurry was stirred at room temperature for 1 h. The formed solid was filtered, washed with water (50 ml) and acetone (25 ml) and dried in vacuum oven at 400C overnight to give zopiclone crude (74.97g .yield 91.7%, purity 98.86% by HPLC).

As the paragraph descriping shows that 55112-42-0 is playing an increasingly important role.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics