With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,75336-86-6
Solid Na2CO3 (200 mg, 1.9 mmol, 1.9 eq) is added to a solution of l-benzyl-4- chlorophthalazine (250 mg, 0.98 mmol, 1 eq) and (i?)-2-methyl-piperazine (400 mg, 4.0 mmol, 4.0 eq) in dioxane (5 mL) in a microwave vial. The vial is sealed and irradiated in the microwave at 150 0C (high absorption setting) for 30 minutes. The reaction mixture is filtered and concentrated, then diluted with EtOAc (50 mL) and water (15 mL). The organic fraction washed with water and then brine, then is dried over sodium sulfate. The solvent is evaporated under reduced pressure to afford the title compound as a white solid (180 mg, 58 percent yield).IH NMR (400 MHz, CHLOROFORM-^) delta ppm 8.08 (d, J=7.07 Hz, 1 H) 8.00 (d, J=7.71 Hz, 1 H) 7.69 – 7.79 (m, 2 H) 7.34 – 7.39 (m, 2 H) 7.25 – 7.32 (m, 2 H) 7.20 (d, J=7.20 Hz, 1 H) 4.61 – 4.65 (m, 2 H) 3.76 – 3.82 (m, 2 H) 3.13 – 3.30 (m, 4 H) 2.85 (dd, ./=12.63, 10.23 Hz, 1 H) 1.17 (d, J=6.32 Hz, 3 H) MS (m/z, MH+): meas. 319.1
As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; WO2008/110611; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics