259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a suspension of tert-butyl 3,3-dimethylpiperazine-l-carboxylate (150 mg, 0.700 mmol) in dioxane (2 mL) were added dicyclohexyl(2′,6′-diisopropoxy-[l,l’-biphenyl]-2-yl)phosphine (Ruphos; 65.3 mg, 0.140 mmol) and N-(4-bromophenyl)methanesulfonamide (193 mg, 0.770 mmol), Ruphos Pd G4 (119 mg, 0.140 mmol), sodium tert-butoxide (336 mg, 3.50 mmol) and the resulting mixture was stirred at 65C for 4 h. The mixture was concentrated and the residue was purified via silica gel chromatography (20 – 100 % EtOAc in hexanes) to give tert-butyl 3,3- dimethyl-4-(4-(methylsulfonamido)phenyl)piperazine-l-carboxylate (173 mg, 0.451 mmol, 64 % yield) as a brown amorphous material. MS (ES+) C18H29N3O4S requires: 383, found: 384 [M+H]+.
259808-67-8, As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.
Reference£º
Patent; TESARO, INC.; LEWIS, Richard T.; JONES, Philip; PETROCCHI, Alessia; REYNA, Naphtali; HAMILTON, Matthew; CROSS, Jason; TREMBLAY, Martin; LEONARD, Paul Graham; (216 pag.)WO2018/136887; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics