109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 2-METHYLPIPERAZINE (2 equivalents) in DICHLOROMETHANE AT-10 C, was added di-tert-butyl dicarbonate (1 equivalent). The mixture was stirred for 10 minutes AT-10 C and was then quenched with saturated aqueous NAHC03. The two phases were separated, and the organic layer was extracted with methylene chloride. The organic extracts were collected, dried (NA2SO4), and concentrated to give the desired tert-butyl 3-methylpiperazine-carboxylate (LC/MS M/Z 201.0 (MH +), Rt 1.67 minutes). Conversion to tert-butyl 4- [2- (4-AMINO-5-FLUORO-2-OXO (3- hydroquinolyl)) benzimidazol-6-yl]-3-methylpiperazinecarboxylate was performed according to the procedure in Example 8 (LC/MS M/Z 493.3 (MH+), Rt 2.45 minutes). Subsequent removal of the Boc group was preformed by bubbling HCI gas into a MeOH solution until saturated (LC/MS M/Z 393.2 (MH +), Rt 1.95 minutes). The free amine was subsequently reacted with paraformaldehyde (5 equivalents) in MeOH: AcOH (5: 1) and NaCNBH4 (4 equivalents) over molecular sieves at 80 C. After 10 hours, the mixture was cooled, filtered, and concentrated. The residue was dissolved in CH2CI2, washed with saturated NAHC03, and dried with NA2SO4 to give the desired 4- AMINO-3-[6-(2, 4-DIMETHYLPIPERAZINYL) BENZIMIDAZOL-2-YL]-5-FLUOROHYDROQUINOLIN- 2-one (LC/MS M/Z 407.3 (MH +), Rt 2.03 minutes). Further purification was performed via reverse phase prep. HPLC.
109-07-9, 109-07-9 2-Methylpiperazine 66057, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics