169447-70-5,169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a solution containing 5-fluoro-2-methyl-3-nitrobenzene (D24, 10 g) and (S)-2-methylpiperazine-1-carboxylic acid tert-butyl ester (12.03 g) in DCM (120 mL) was added acetic acid (3.28 g) dropwise. The mixture was stirred at room temperature for one hour. Sodium triacetoxyborohydride (23.15 g) was added to the ice bath. The mixture was stirred overnight at room temperature,The reaction was stopped using saturated NaHC03 solution. The organic layer was dehydrated with anhydrous Na2SO4, filtered, and concentrated in vacuo to give the title compound (22.17 g) as a slurry.
The synthetic route of 169447-70-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; LEI, HUI; MA, XIN; REN, FENG; LIN, XICHEN; MARQUIS, ROBERT W., JR; (139 pag.)TW2017/14884; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics