New learning discoveries about 129799-08-2

129799-08-2, As the paragraph descriping shows that 129799-08-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129799-08-2,1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

Preparation of 1-tert-butyl 3-methyl 4-(4′-chloro-2′-fluoro-4-nitrobiphenyl-3-carbonyl)piperazine-1,3-dicarboxylate (6)Starting material 5 (708 mg, 2.9 mmol) in 20 ml of dichloromethane is initially introduced in a 50 ml multinecked flask with dropping funnel, thermometer and N2 inlet lube, and 1.7 ml of DIPEA are added. The solution is cooled to 0 C., and a solution of 900 mg (3 mmol) of starting material 4 in 10 ml of dichloro-methane is added dropwise over the course of 15 min with stirring. The ice bath is then removed, and the mixture is stirred for a further one hour. Water is added to the reaction mixture, the organic phase is separated off, dried over sodium sulfate, and the solvent is removed. The residue is filtered absorptively through a silica-gel column with ethyl acetate, and the filtrate is evaporated to dryness. The desired product 6 is obtained in a yield of 80% (1.5 g, 2.3 mmol) as solid (mass: [M*-(tBu)]=266; RT 3.44 min. HPLC method 1-100-2_Speed).

129799-08-2, As the paragraph descriping shows that 129799-08-2 is playing an increasingly important role.

Reference£º
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2012/115852; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics