Analyzing the synthesis route of 1-(4-Trifluoromethylphenyl)piperazine

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 26 To a solution of Compound B (0.2 g, 0.54 mmol) in acetonitrile (5 mL) at room temperature were added diisopropylethylamine (0.4 mL, 2.3 mmol) and 1-(4-trifluoromethylphenyl)piperazine (0.187 g, 0.81 mmol) and the reaction mixture was heated to 80 C. On heating, the reaction mixture became clear and after 15 min commencement of precipitation of solid was observed. Heating was continued for 3 hr and then the reaction mixture was cooled. The solid obtained was collected by filtration, washed with acetonitrile and dried under vacuum. LC/MS: (M+H)+: 565. An NMR spectrum is provided in FIG. 26.Yield: 0.22 g (72%).

30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sudhakar, Anantha; US2011/105497; (2011); A1;,
Piperazine – Wikipedia
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