122833-04-9, 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
10222] Step 4. To a suspension of 2-methoxy-4-(4-meth- ylpiperazin- 1 -yl)aniline (Green Chempharm; 3.45 g, 15.57 mmol) and N-(3-(5-methyl-2-(methylsulfinyl)-7-oxopyrido [2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide (Sb) (4.59 g, 12.46 mmol) in anhydrous tert-butanol (40 mE) and dioxane (5 mE) at RT was added DIEA (4.33 mE, 24.92 mmol). The mixture was heated at 1000 C. for 40 h. The reaction mixture was concentrated under reduced pressure (rotary evaporator) to remove the volatiles and the resulting crude residue was suspended in Et20 and filtered. The greenish-brown amorphous solid was washed with Et20 (3×50 mE) and this removed most of the remaining aniline starting material. The crude material was dry-packed on silica gel and purified on a silica gel column (1-20% MeOH in DCM) affording N-(3- (2-((2-methoxy-4-(4-methylpiperazin-1 -yl)phenyl)amino)5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)acrylamide (5) (2.03 g, 3.86 mmol, 31% yield) as a yellow amorphous solid. m/z (ESI, +ve ion) 526.2 (M+H). ?H NMR (400 MHz, DMSO-d5) oe ppm 10.33 (1H, s), 8.80 (1H, s), 8.09 (1H, s), 7.88 (1H, d, J=8.2 Hz), 7.56 (1H, J=1 .9Hz), 7.50 (1H, t, 1=8.1 Hz), 7.27 (1H, d, J=8.8 Hz), 6.97 (1H, dt, J=6.9, 1.0 Hz), 6.52 (1H, d, J=2.5 Hz), 6.37-6.48 (1H, m), 6.29-6.35 (1H, m), 6.19-6.29 (1H, m), 6.01 (1H, bt s.), 5.71-5.80 (1H, m), 3.78 (3H, s), 3.02 (4H, bt s.), 2.46 (3H, s), 2.43 (4H, t, J=4.9 Hz), 2.22 (3H, s)., 122833-04-9
As the paragraph descriping shows that 122833-04-9 is playing an increasingly important role.
Reference£º
Patent; TASKER, Andrew; WURZ, Ryan; PETTUS, Liping H.; HERBERICH, Bradley J.; US2014/249131; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics