With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
To a solution of methyl 2-[1-(3-ethylphenyl)cyclopentyl]ethanimidate hydrochloride (2.0 g) and 1-methylpiperazin-2-one (1.62 g) in THE (150 ml) was added at 22¡ãC diisopropylethyl amine (1.83 g) and after 5 mm acetic acid (426 mg) and stirring was continued at 22¡ãC for 16 h. The mixture can be further processed as described below or the intermediate 4-[2-[1-(3- ethylphenyl)cyclopentyl]ethanimidoyl]-1 -methyl-piperazin-2-one hydrochloride can be isolated by dilution with ethyl ether followed by filtration and drying of the residue.The mixture containing the intermediate was cooled down to -30¡ãC, a solution of lithium hexamethyldisilazide in THF (1M, 50 ml) was added followed by diethyl oxalate (4.15 g) and stirring was continued at -30¡ãC. In case of incomplete conversion a further portion of lithium hexamethyldisilazide and diethyl oxalate has to be added. The mixture was warmed to 22¡ãC, partitioned between aqueous hydrochloric acid (1 N) and dichloromethane, the organic layerwas dried, evaporated, the residue triturated with diethyl ether, filtered and the residue dried to give example 1 (1.40 g) as a white powder. Alternatively, the crude material can purified by preparative HPLC (RP-18, MeCN/H20 containing 0.23percent of HCOOH).MS (ESI, mlz): 382.3 [(M+H)]
59702-07-7, As the paragraph descriping shows that 59702-07-7 is playing an increasingly important role.
Reference£º
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; LERNER, Christian; KREIS, Lukas; WEIKERT, Robert James; NEIDHART, Werner; HILPERT, Hans; (97 pag.)WO2017/158147; (2017); A1;,
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