Analyzing the synthesis route of 1-(Cyclopropylcarbonyl)piperazine

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.,59878-57-8

General procedure: A solution of 1,1?-carbonyldiimidazole (CDI) in THF (3 ml, 3.7 mmol) was added to indole-2-carboxylic acid (3.1 mmol) in THF (5 ml) at room temperature and stirred for 1 hunder N2. Then, the reaction mixture was cooled to 0d fC andN-substituted piperazine derivatives (3.7 mmol) in THF (3ml) were added and stirred for further 17-18 h at roomtemperature. Basic workup (CHCl3, sat. NaHCO3) wasapplied, evaporated under vacuo and recrystallization fromethyl acetate:n-hexane provided the desired compounds (1,4-15, Scheme 1).

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Article; Altuntas, Tunca Gul; Yilmaz, Niluefer; Coban, Tuelay; Oelgen, Suereyya; Letters in drug design and discovery; vol. 14; 4; (2017); p. 380 – 386;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics