With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-81-3,1-Methyl-4-(4-nitrobenzyl)piperazine,as a common compound, the synthetic route is as follows.
70261-81-3, 8.5 g (36.2 mmol) of crude I-a, 2.0 g of FeO(OH)/C catalyst and 100 mL of 95% ethanol were added to a 500 mL one-necked flask, and the mixture was heated under reflux, and a mixture of 25 mL of hydrazine hydrate and 20 mL of 95% ethanol was slowly added dropwise. The disappearance of the starting material by TLC (methanol: chloroform = 1:15). The filter cake was washed twice with hot ethanol (30 mL ¡Á 2). The solvent was evaporated under reduced pressure to give a white solid. Vacuum drying (I-a’) 6.7 g, The yield was 90.3%. The product was directly fed to the next reaction without further purification.
The synthetic route of 70261-81-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shanghai Fuxing Pharmaceutical Industrial Co., Ltd.; Lu Shuai; Jin Qiaomei; Wang Yue; Chen Yadong; Lu Tao; (54 pag.)CN104592251; (2019); B;,
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