With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: The mixtures of (1,1′-thiocarbonyl) bis-1H-imidazole (5 mmol)and suitable derivative of piperazine or thiomorpholine (5 mmol)in methylene chloride (25 ml) were stirred for 24 h at room temperature.The solutions were extracted three times with distilledwater and the organic phases were dried over MgSO4 and evaporated. The obtained thioketones were refluxed for 2 h withhydrazine hydrate (5 mmol). The final thiosemicarbazides werecrystallized from dry methanol.
30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.
Reference£º
Article; Mrozek-Wilczkiewicz, Anna; Malarz, Katarzyna; Rejmund, Marta; Polanski, Jaroslaw; Musiol, Robert; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 180 – 194;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics