With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step 1: 1-BOC-3-Methylpiperazine (1.00 g) was combined with dichloromethane (10 mL), diisopropylethylamine (0.94 mL) and N-(benzyloxy-carbonyloxy)succinimide. The reaction was stirred at room temperature for 3 days and concentrated to dryness. The residue was diluted with ethyl acetate (20 mL) and washed with HCl (1 N in water, 3*5 mL), saturated aqueous sodium bicarbonate (3*5 mL) and brine (5 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated giving the desired benzyl carbamate. Yield=100percent, 120737-59-9
The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Millennium Pharmaceuticals, Inc.; US2003/153556; (2003); A1;,
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