With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1001180-21-7,(R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Example 13aTert-butyl 4- [(5R,7R)-7-hydroxy-5-methyl-6,7-dihydrocyclopentaldl pyrimidin-4- yllpiperazine-1-carboxylate mM Potassium dihydrogen phosphate pH 7.2), 78 g 2-Propanol and 50 mg NAD (75iimol) was formed under vigorous stirring. The reduction started by the addition of 500 mg KRED-X1.1- P1 FO 1. The reaction mixture is sparged with nitrogen and heated to 40C for 22 hours. After reaction completion 174 g isopropylacetate are added, agitated, phases were split and the5 aqueous phase removed. The aqueous phase was extracted again with 174 g isopropylacetate. The aqueous phase was removed and the organic phases were combined and concentrated at 35C in vacuo to a final volume of 115 mL. At the same temperature 212 g Heptane are added within 1 hour, the suspension is aged for 1 hour and cooled to 10C within 6 hours. The suspension is filtered and washed with 68g heptane. After drying of the filter cake for 4 hours at10 50C and 41.1 g (82% yield, purity 100% area) white crystals are obtained.
1001180-21-7, 1001180-21-7 (R)-tert-Butyl 4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate 59580350, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; IDING, Hans; REENTS, Reinhard; SCALONE, Michelangelo; GOSSELIN, Francis; WO2015/73739; (2015); A1;,
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